Status of, and strategies for improving, adherence to HCC screening and surveillance
Giampiero Francica,1 Mauro Borzio21Unità Operativa Ecografia ed Ecointerventistica, Pineta Grande Hospital, Castel Volturno, Italy; 2Unità Operativa Complessa Gastroenterologia ed Endoscopia Digestiva, Azienda Socio Sanitaria TerritorialeMelegnano e della Martesana, Milano, Ita...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-07-01
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| Series: | Journal of Hepatocellular Carcinoma |
| Subjects: | |
| Online Access: | https://www.dovepress.com/status-of-and-strategies-for-improving-adherence-to-hcc-screening-and--peer-reviewed-article-JHC |
| _version_ | 1819050979745595392 |
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| author | Francica G Borzio M |
| author_facet | Francica G Borzio M |
| author_sort | Francica G |
| collection | DOAJ |
| description | Giampiero Francica,1 Mauro Borzio21Unità Operativa Ecografia ed Ecointerventistica, Pineta Grande Hospital, Castel Volturno, Italy; 2Unità Operativa Complessa Gastroenterologia ed Endoscopia Digestiva, Azienda Socio Sanitaria TerritorialeMelegnano e della Martesana, Milano, ItalyAbstract: Hepatocellular carcinoma (HCC) represents the second leading cause of cancer deaths worldwide and the main cause of death in patients with cirrhosis. Secondary prevention of HCC can be accomplished through the serial application of screening tests (ultrasound with or without alpha-fetoprotein) to detect the presence of subclinical lesions amenable to potentially curative treatment, such as surgery and ablation. The efficacy of HCC screening is accepted by hepatologists in terms of decline in cancer-specific mortality, but its translation into clinical practice is less than ideal. The effectiveness of HCC screening is hampered by several factors: failure to identify at-risk patients, failure to access care and failure to detect HCC. For each of these steps, possible improvements are discussed in order to face the changing etiology of cirrhosis and expand the screening of at-risk populations by including selected nonalcoholic fatty liver disease patients.Keywords: cirrhosis, hepatocellular carcinoma, ultrasound, alpha-fetoprotein, screening |
| first_indexed | 2024-12-21T11:56:39Z |
| format | Article |
| id | doaj.art-a97901ae6d524b6ca6ea78469d36b6ab |
| institution | Directory Open Access Journal |
| issn | 2253-5969 |
| language | English |
| last_indexed | 2024-12-21T11:56:39Z |
| publishDate | 2019-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj.art-a97901ae6d524b6ca6ea78469d36b6ab2022-12-21T19:04:56ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692019-07-01Volume 613114147377Status of, and strategies for improving, adherence to HCC screening and surveillanceFrancica GBorzio MGiampiero Francica,1 Mauro Borzio21Unità Operativa Ecografia ed Ecointerventistica, Pineta Grande Hospital, Castel Volturno, Italy; 2Unità Operativa Complessa Gastroenterologia ed Endoscopia Digestiva, Azienda Socio Sanitaria TerritorialeMelegnano e della Martesana, Milano, ItalyAbstract: Hepatocellular carcinoma (HCC) represents the second leading cause of cancer deaths worldwide and the main cause of death in patients with cirrhosis. Secondary prevention of HCC can be accomplished through the serial application of screening tests (ultrasound with or without alpha-fetoprotein) to detect the presence of subclinical lesions amenable to potentially curative treatment, such as surgery and ablation. The efficacy of HCC screening is accepted by hepatologists in terms of decline in cancer-specific mortality, but its translation into clinical practice is less than ideal. The effectiveness of HCC screening is hampered by several factors: failure to identify at-risk patients, failure to access care and failure to detect HCC. For each of these steps, possible improvements are discussed in order to face the changing etiology of cirrhosis and expand the screening of at-risk populations by including selected nonalcoholic fatty liver disease patients.Keywords: cirrhosis, hepatocellular carcinoma, ultrasound, alpha-fetoprotein, screeninghttps://www.dovepress.com/status-of-and-strategies-for-improving-adherence-to-hcc-screening-and--peer-reviewed-article-JHCCirrhosisHepatocellular CarcinomaUltrasoundAlpha-fetoproteinScreening |
| spellingShingle | Francica G Borzio M Status of, and strategies for improving, adherence to HCC screening and surveillance Journal of Hepatocellular Carcinoma Cirrhosis Hepatocellular Carcinoma Ultrasound Alpha-fetoprotein Screening |
| title | Status of, and strategies for improving, adherence to HCC screening and surveillance |
| title_full | Status of, and strategies for improving, adherence to HCC screening and surveillance |
| title_fullStr | Status of, and strategies for improving, adherence to HCC screening and surveillance |
| title_full_unstemmed | Status of, and strategies for improving, adherence to HCC screening and surveillance |
| title_short | Status of, and strategies for improving, adherence to HCC screening and surveillance |
| title_sort | status of and strategies for improving adherence to hcc screening and surveillance |
| topic | Cirrhosis Hepatocellular Carcinoma Ultrasound Alpha-fetoprotein Screening |
| url | https://www.dovepress.com/status-of-and-strategies-for-improving-adherence-to-hcc-screening-and--peer-reviewed-article-JHC |
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