The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase
One goal of potato breeding is to reduce the accumulation of toxic solanidane glycoalkaloids. Here the authors show that potato DPS, a 2-oxoglutarate dependent dioxygenase, catalyzes ring rearrangement of a biosynthetic precursor to differentiate solanidanes from spirosolanes that are found in other...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21546-0 |
| _version_ | 1818735299409215488 |
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| author | Ryota Akiyama Bunta Watanabe Masaru Nakayasu Hyoung Jae Lee Junpei Kato Naoyuki Umemoto Toshiya Muranaka Kazuki Saito Yukihiro Sugimoto Masaharu Mizutani |
| author_facet | Ryota Akiyama Bunta Watanabe Masaru Nakayasu Hyoung Jae Lee Junpei Kato Naoyuki Umemoto Toshiya Muranaka Kazuki Saito Yukihiro Sugimoto Masaharu Mizutani |
| author_sort | Ryota Akiyama |
| collection | DOAJ |
| description | One goal of potato breeding is to reduce the accumulation of toxic solanidane glycoalkaloids. Here the authors show that potato DPS, a 2-oxoglutarate dependent dioxygenase, catalyzes ring rearrangement of a biosynthetic precursor to differentiate solanidanes from spirosolanes that are found in other solanaceous plants. |
| first_indexed | 2024-12-18T00:19:03Z |
| format | Article |
| id | doaj.art-a979c63a4d054a6391ecae62f87f29bb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:19:03Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a979c63a4d054a6391ecae62f87f29bb2022-12-21T21:27:24ZengNature PortfolioNature Communications2041-17232021-02-0112111010.1038/s41467-021-21546-0The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenaseRyota Akiyama0Bunta Watanabe1Masaru Nakayasu2Hyoung Jae Lee3Junpei Kato4Naoyuki Umemoto5Toshiya Muranaka6Kazuki Saito7Yukihiro Sugimoto8Masaharu Mizutani9Graduate School of Agricultural Science, Kobe UniversityInstitute for Chemical Research, Kyoto UniversityGraduate School of Agricultural Science, Kobe UniversityGraduate School of Agricultural Science, Kobe UniversityGraduate School of Agricultural Science, Kobe UniversityRIKEN Center for Sustainable Resource ScienceDepartment of Biotechnology, Graduate School of Engineering, Osaka UniversityRIKEN Center for Sustainable Resource ScienceGraduate School of Agricultural Science, Kobe UniversityGraduate School of Agricultural Science, Kobe UniversityOne goal of potato breeding is to reduce the accumulation of toxic solanidane glycoalkaloids. Here the authors show that potato DPS, a 2-oxoglutarate dependent dioxygenase, catalyzes ring rearrangement of a biosynthetic precursor to differentiate solanidanes from spirosolanes that are found in other solanaceous plants.https://doi.org/10.1038/s41467-021-21546-0 |
| spellingShingle | Ryota Akiyama Bunta Watanabe Masaru Nakayasu Hyoung Jae Lee Junpei Kato Naoyuki Umemoto Toshiya Muranaka Kazuki Saito Yukihiro Sugimoto Masaharu Mizutani The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase Nature Communications |
| title | The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase |
| title_full | The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase |
| title_fullStr | The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase |
| title_full_unstemmed | The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase |
| title_short | The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase |
| title_sort | biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase |
| url | https://doi.org/10.1038/s41467-021-21546-0 |
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