Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts

Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts

Abstract Background Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in hepatocellular carcinoma, acute myeloid leukemia and melanoma. This study aims to investigate the effects of PEG-BCT-100 in MPM. Meth...

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Bibliographic Details
Main Authors: Sze-Kwan Lam, Yuan-Yuan Li, Shi Xu, Leanne Lee Leung, Kin-Pong U, Yan-Fang Zheng, Paul Ning-Man Cheng, James Chung-Man Ho
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Respiratory Research
Subjects:
Mesothelioma
Pegylated arginase
BCT-100
Apoptosis
Cell cycle arrest
Xenografts
Online Access:http://link.springer.com/article/10.1186/s12931-017-0564-3

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