Tumor Necrosis Factor-α Produced by Osteoclasts Might Induce Intractable Pain in a Rat Spinal Metastasis Model of Breast Cancer

Tumor Necrosis Factor-α Produced by Osteoclasts Might Induce Intractable Pain in a Rat Spinal Metastasis Model of Breast Cancer

Introduction: Causes of pain due to spinal metastases have been insufficiently investigated. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were the focus of this study. Both are known as proinflammatory cytokines associated with the pathophysiology of pain syndromes. It is well known that...

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Bibliographic Details
Main Authors: Ai Mazaki, Sumihisa Orita, Kazuhide Inage, Miyako Suzuki, Kohki Abe, Yasuhiro Shiga, Masahiro Inoue, Masaki Norimoto, Tomotaka Umimura, Seiji Ohtori, Kazuyo Yamauchi
Format: Article
Language:English
Published: The Japanese Society for Spine Surgery and Related Research 2019-07-01
Series:Spine Surgery and Related Research
Subjects:
osteoclast
tnf-α
il-6
proinflammatory cytokines
spinal metastasis
breast cancer
pain
Online Access:https://www.jstage.jst.go.jp/article/ssrr/3/3/3_2018-0106/_pdf/-char/en

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