The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster

The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster

The miR-17-92 cluster is involved in animal development and homeostasis, and its dysregulation leads to human diseases such as cancer. In the present study, we investigated the functional link between miR-17-92 cluster and Wnt/β-catenin signaling pathway in ICP2 and DF1 cells. We demonstrated that e...

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Bibliographic Details
Main Authors: Fang Mu, Jiaxin Huang, Tianyu Xing, Yang Jing, Tingting Cui, Yaqi Guo, Xiaohong Yan, Hui Li, Ning Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
LEF1
miR-17-92 cluster host gene (MIR17HG)
Wnt/β-catenin pathway
target gene
cell proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00525/full

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