Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System
The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartment...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/11/1862 |
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| author | Emily Dosmar Gabrielle Vuotto Xingqi Su Emily Roberts Abigail Lannoy Garet J. Bailey William F. Mieler Jennifer J. Kang-Mieler |
| author_facet | Emily Dosmar Gabrielle Vuotto Xingqi Su Emily Roberts Abigail Lannoy Garet J. Bailey William F. Mieler Jennifer J. Kang-Mieler |
| author_sort | Emily Dosmar |
| collection | DOAJ |
| description | The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartmental and four COMSOL models of the eye were developed to describe transport into the vitreous originating from a DDS placed topically, in the subconjunctiva, subretinally, and intravitreally. The concentration of the simulated DDS was assumed to be the initial concentration of the hydrogel DDS. The simulation was executed over 1500 and 100 h for the compartmental and COMSOL models, respectively. Based on the MATLAB model, topical, subconjunctival, subretinal and vitreous administration took most (~500 h to least (0 h) amount of time to reach peak concentrations in the vitreous, respectively. All routes successfully achieved therapeutic levels of drug (0.007 mg/mL) in the vitreous. These models predict the relative build-up of drug in the vitreous following DDS administration in four different points of origin in the eye. Our model may eventually be used to explore the minimum loading dose of drug required in our DDS leading to reduced drug use and waste. |
| first_indexed | 2024-03-10T05:09:14Z |
| format | Article |
| id | doaj.art-a97dccf7d2ef4faf9cfcbbb4ff1e9c77 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T05:09:14Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a97dccf7d2ef4faf9cfcbbb4ff1e9c772023-11-23T00:58:44ZengMDPI AGPharmaceutics1999-49232021-11-011311186210.3390/pharmaceutics13111862Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery SystemEmily Dosmar0Gabrielle Vuotto1Xingqi Su2Emily Roberts3Abigail Lannoy4Garet J. Bailey5William F. Mieler6Jennifer J. Kang-Mieler7Department of Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, 5500 Wabash Avenue, Terre Haute, IN 47803, USADepartment of Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, 5500 Wabash Avenue, Terre Haute, IN 47803, USADepartment of Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, 5500 Wabash Avenue, Terre Haute, IN 47803, USADepartment of Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, 5500 Wabash Avenue, Terre Haute, IN 47803, USADepartment of Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, 5500 Wabash Avenue, Terre Haute, IN 47803, USADepartment of Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, 5500 Wabash Avenue, Terre Haute, IN 47803, USADepartment of Biomedical Engineering, Illinois Institute of Technology, 10 W 35th St., Chicago, IL 60616, USADepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1200 W Harrison St., Chicago, IL 60607, USAThe purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartmental and four COMSOL models of the eye were developed to describe transport into the vitreous originating from a DDS placed topically, in the subconjunctiva, subretinally, and intravitreally. The concentration of the simulated DDS was assumed to be the initial concentration of the hydrogel DDS. The simulation was executed over 1500 and 100 h for the compartmental and COMSOL models, respectively. Based on the MATLAB model, topical, subconjunctival, subretinal and vitreous administration took most (~500 h to least (0 h) amount of time to reach peak concentrations in the vitreous, respectively. All routes successfully achieved therapeutic levels of drug (0.007 mg/mL) in the vitreous. These models predict the relative build-up of drug in the vitreous following DDS administration in four different points of origin in the eye. Our model may eventually be used to explore the minimum loading dose of drug required in our DDS leading to reduced drug use and waste.https://www.mdpi.com/1999-4923/13/11/1862targeted drug deliveryocular drug deliverycompartmental modelingpharmacokinetic modelingCOMSOL 3D modelinghydrogels |
| spellingShingle | Emily Dosmar Gabrielle Vuotto Xingqi Su Emily Roberts Abigail Lannoy Garet J. Bailey William F. Mieler Jennifer J. Kang-Mieler Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System Pharmaceutics targeted drug delivery ocular drug delivery compartmental modeling pharmacokinetic modeling COMSOL 3D modeling hydrogels |
| title | Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System |
| title_full | Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System |
| title_fullStr | Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System |
| title_full_unstemmed | Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System |
| title_short | Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System |
| title_sort | compartmental and comsol multiphysics 3d modeling of drug diffusion to the vitreous following the administration of a sustained release drug delivery system |
| topic | targeted drug delivery ocular drug delivery compartmental modeling pharmacokinetic modeling COMSOL 3D modeling hydrogels |
| url | https://www.mdpi.com/1999-4923/13/11/1862 |
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