Inflammation mediated the effect of dietary fiber on depressive symptoms
Background and aimsPrevious studies showed that inflammation affects depressive symptoms. Dietary fiber may be associated with inflammation and depressive symptoms. We aimed to investigate the relationship between inflammation and depressive symptoms at different levels of dietary fiber intake and t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.989492/full |
| _version_ | 1797956055452352512 |
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| author | Ting Zhang Ting Zhang Xiao-mei Cui Yu-ying Zhang Tao Xie Yuan-jia Deng Fang-xi Guo Qi Wang Qing-feng Wu Ming-hua Dong Xiao-ting Luo Xiao-ting Luo |
| author_facet | Ting Zhang Ting Zhang Xiao-mei Cui Yu-ying Zhang Tao Xie Yuan-jia Deng Fang-xi Guo Qi Wang Qing-feng Wu Ming-hua Dong Xiao-ting Luo Xiao-ting Luo |
| author_sort | Ting Zhang |
| collection | DOAJ |
| description | Background and aimsPrevious studies showed that inflammation affects depressive symptoms. Dietary fiber may be associated with inflammation and depressive symptoms. We aimed to investigate the relationship between inflammation and depressive symptoms at different levels of dietary fiber intake and to explore whether dietary fiber affects depression through inflammation.MethodsA total of 8,430 National Health and Nutrition Examination Survey (NHANES) samples were collected between 2015 and 2018. Factor analysis was used to determine dietary patterns. Linear regression and logistic regression analysis were used to explore the relationship between nutrients, inflammation, and depressive symptoms, and the mediation analysis was conducted using the bootstrap method.ResultsFactor 3 (dietary fiber and vitamins) was inversely associated with depressive symptoms and inflammation. The upper quartile scores of the dietary inflammatory index (DII) and C-reactive protein (CRP) were associated with depressive symptoms compared with controls (DII: OR = 1.851, 95% CI: 1.267–2.705; CRP: OR = 1.737, 95% CI: 1.136–2.656). The DII score and CRP were associated with depressive symptoms in the group with low dietary fiber intake (DII: OR = 2.736, 95% CI: 1.628–4.598; CRP: OR = 2.092, 95% CI: 1.196–3.658) but not in the high dietary fiber intake group. Mediating analysis showed that CRP partially mediated the effect of dietary fiber intake on depressive symptoms (βindirect = −0.0025, 95% CI: −0.0038 to −0.0013), and the mediated proportion was 10.5%.ConclusionIn this study, we found that DII scores and CRP were not associated with depressive symptoms in participants with high dietary fiber intake, and inflammation partially mediates the effect of dietary fiber on depressive symptoms. |
| first_indexed | 2024-04-10T23:42:55Z |
| format | Article |
| id | doaj.art-a97e8a7f48db421b8b900dfd72d74262 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-10T23:42:55Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-a97e8a7f48db421b8b900dfd72d742622023-01-11T05:41:31ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-01-011310.3389/fpsyt.2022.989492989492Inflammation mediated the effect of dietary fiber on depressive symptomsTing Zhang0Ting Zhang1Xiao-mei Cui2Yu-ying Zhang3Tao Xie4Yuan-jia Deng5Fang-xi Guo6Qi Wang7Qing-feng Wu8Ming-hua Dong9Xiao-ting Luo10Xiao-ting Luo11Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, ChinaSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, ChinaSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, ChinaSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, ChinaSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, ChinaSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, ChinaDepartment of Epidemiology, Gannan Medical University, Ganzhou, ChinaDepartment of Epidemiology, Gannan Medical University, Ganzhou, ChinaDepartment of Epidemiology, Gannan Medical University, Ganzhou, ChinaKey Laboratory of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaDepartment of General Practice, Gannan Medical University, Ganzhou, ChinaBackground and aimsPrevious studies showed that inflammation affects depressive symptoms. Dietary fiber may be associated with inflammation and depressive symptoms. We aimed to investigate the relationship between inflammation and depressive symptoms at different levels of dietary fiber intake and to explore whether dietary fiber affects depression through inflammation.MethodsA total of 8,430 National Health and Nutrition Examination Survey (NHANES) samples were collected between 2015 and 2018. Factor analysis was used to determine dietary patterns. Linear regression and logistic regression analysis were used to explore the relationship between nutrients, inflammation, and depressive symptoms, and the mediation analysis was conducted using the bootstrap method.ResultsFactor 3 (dietary fiber and vitamins) was inversely associated with depressive symptoms and inflammation. The upper quartile scores of the dietary inflammatory index (DII) and C-reactive protein (CRP) were associated with depressive symptoms compared with controls (DII: OR = 1.851, 95% CI: 1.267–2.705; CRP: OR = 1.737, 95% CI: 1.136–2.656). The DII score and CRP were associated with depressive symptoms in the group with low dietary fiber intake (DII: OR = 2.736, 95% CI: 1.628–4.598; CRP: OR = 2.092, 95% CI: 1.196–3.658) but not in the high dietary fiber intake group. Mediating analysis showed that CRP partially mediated the effect of dietary fiber intake on depressive symptoms (βindirect = −0.0025, 95% CI: −0.0038 to −0.0013), and the mediated proportion was 10.5%.ConclusionIn this study, we found that DII scores and CRP were not associated with depressive symptoms in participants with high dietary fiber intake, and inflammation partially mediates the effect of dietary fiber on depressive symptoms.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.989492/fulldepressionnutritiondietary fiberdietary inflammatory indexCRP |
| spellingShingle | Ting Zhang Ting Zhang Xiao-mei Cui Yu-ying Zhang Tao Xie Yuan-jia Deng Fang-xi Guo Qi Wang Qing-feng Wu Ming-hua Dong Xiao-ting Luo Xiao-ting Luo Inflammation mediated the effect of dietary fiber on depressive symptoms Frontiers in Psychiatry depression nutrition dietary fiber dietary inflammatory index CRP |
| title | Inflammation mediated the effect of dietary fiber on depressive symptoms |
| title_full | Inflammation mediated the effect of dietary fiber on depressive symptoms |
| title_fullStr | Inflammation mediated the effect of dietary fiber on depressive symptoms |
| title_full_unstemmed | Inflammation mediated the effect of dietary fiber on depressive symptoms |
| title_short | Inflammation mediated the effect of dietary fiber on depressive symptoms |
| title_sort | inflammation mediated the effect of dietary fiber on depressive symptoms |
| topic | depression nutrition dietary fiber dietary inflammatory index CRP |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.989492/full |
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