Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification

Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification

Cholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we compared the efficacy and duration of silencing induced by cholesterol conjugates of selectively and totally modified siRNAs and their heterodu...

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Bibliographic Details
Main Authors: Ivan V. Chernikov, Ul’yana A. Ponomareva, Mariya I. Meschaninova, Irina K. Bachkova, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
siRNA
chemical modifications
cholesterol conjugate
nuclease resistance
duration of silencing
<i>MDR1</i> gene
Online Access:https://www.mdpi.com/1420-3049/29/4/786

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