Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer
Abstract Transurethral resection of bladder tumor (TUR-BT) and radical cystectomy (RC) are standard treatment options for bladder cancer (BC). Neoadjuvant chemotherapy (NAC) prior to RC improves outcome of some patients but currently there are no valid biomarkers to identify patients who benefit fro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-93245-1 |
| _version_ | 1831570629610962944 |
|---|---|
| author | Matias Blomqvist Ilmari Koskinen Eliisa Löyttyniemi Tuomas Mirtti Peter J. Boström Pekka Taimen |
| author_facet | Matias Blomqvist Ilmari Koskinen Eliisa Löyttyniemi Tuomas Mirtti Peter J. Boström Pekka Taimen |
| author_sort | Matias Blomqvist |
| collection | DOAJ |
| description | Abstract Transurethral resection of bladder tumor (TUR-BT) and radical cystectomy (RC) are standard treatment options for bladder cancer (BC). Neoadjuvant chemotherapy (NAC) prior to RC improves outcome of some patients but currently there are no valid biomarkers to identify patients who benefit from NAC. Presence of cancer stem cells (CSC) has been associated with poor outcome and resistance to chemotherapy in various cancers. Here we studied the expression of stem cell markers ALDH1, SOX2 and SSEA-4 with immunohistochemistry in tissue microarray material consisting of 195 BC patients treated with RC and 74 patients treated with TUR-BT followed by NAC and RC. Post-operative follow-up data of up to 22 years was used. Negative to weak cytoplasmic SOX2 staining was associated with lymphovascular invasion and non-organ confined disease. It was also associated with shortened cancer-specific survival, but the finding was not statistically significant. Contrary to previous reports, none of the other tested biomarkers were associated with cancer-specific mortality or clinicopathological characteristics. Neither were they associated with response to NAC. Despite the promising results of previously published studies, our results suggest that CSC markers ALDH1, SOX2 and SSEA-4 have little if any prognostic or predictive value in BC treated with RC. |
| first_indexed | 2024-12-17T12:54:40Z |
| format | Article |
| id | doaj.art-a983ad99b731480d86231b5faa38df2f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T12:54:40Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a983ad99b731480d86231b5faa38df2f2022-12-21T21:47:30ZengNature PortfolioScientific Reports2045-23222021-07-011111910.1038/s41598-021-93245-1Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancerMatias Blomqvist0Ilmari Koskinen1Eliisa Löyttyniemi2Tuomas Mirtti3Peter J. Boström4Pekka Taimen5Institute of Biomedicine and FICAN West Cancer Centre, University of TurkuDepartment of Urology, Helsinki University Hospital and University of HelsinkiDepartment of Biostatistics, University of TurkuDepartment of Pathology, University of Helsinki and Helsinki University HospitalDepartment of Urology and FICAN West Cancer Centre, University of Turku and Turku University HospitalInstitute of Biomedicine and FICAN West Cancer Centre, University of TurkuAbstract Transurethral resection of bladder tumor (TUR-BT) and radical cystectomy (RC) are standard treatment options for bladder cancer (BC). Neoadjuvant chemotherapy (NAC) prior to RC improves outcome of some patients but currently there are no valid biomarkers to identify patients who benefit from NAC. Presence of cancer stem cells (CSC) has been associated with poor outcome and resistance to chemotherapy in various cancers. Here we studied the expression of stem cell markers ALDH1, SOX2 and SSEA-4 with immunohistochemistry in tissue microarray material consisting of 195 BC patients treated with RC and 74 patients treated with TUR-BT followed by NAC and RC. Post-operative follow-up data of up to 22 years was used. Negative to weak cytoplasmic SOX2 staining was associated with lymphovascular invasion and non-organ confined disease. It was also associated with shortened cancer-specific survival, but the finding was not statistically significant. Contrary to previous reports, none of the other tested biomarkers were associated with cancer-specific mortality or clinicopathological characteristics. Neither were they associated with response to NAC. Despite the promising results of previously published studies, our results suggest that CSC markers ALDH1, SOX2 and SSEA-4 have little if any prognostic or predictive value in BC treated with RC.https://doi.org/10.1038/s41598-021-93245-1 |
| spellingShingle | Matias Blomqvist Ilmari Koskinen Eliisa Löyttyniemi Tuomas Mirtti Peter J. Boström Pekka Taimen Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer Scientific Reports |
| title | Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer |
| title_full | Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer |
| title_fullStr | Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer |
| title_full_unstemmed | Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer |
| title_short | Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer |
| title_sort | prognostic and predictive value of aldh1 sox2 and ssea 4 in bladder cancer |
| url | https://doi.org/10.1038/s41598-021-93245-1 |
| work_keys_str_mv | AT matiasblomqvist prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT ilmarikoskinen prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT eliisaloyttyniemi prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT tuomasmirtti prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT peterjbostrom prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT pekkataimen prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer |