GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION
The susceptibility of the great gerbil to the causative agent of plague is genetically determined. However, there is not enough information on the involved genes and their effect on this feature in the literature. Although the sensitivity of gerbils to plague microbe may depend on many genes, thi...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2018-07-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/643 |
| _version_ | 1797237354104094720 |
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| author | V. V. Sutyagin T. V. Meka-Mechenko G. G. Kovaleva A. T. Berdibekov |
| author_facet | V. V. Sutyagin T. V. Meka-Mechenko G. G. Kovaleva A. T. Berdibekov |
| author_sort | V. V. Sutyagin |
| collection | DOAJ |
| description | The susceptibility of the great gerbil to the causative agent of plague is genetically determined. However, there is not enough information on the involved genes and their effect on this feature in the literature. Although the sensitivity of gerbils to plague microbe may depend on many genes, this feature can be described using a monogenic model of inheritance with one gene. In addition to the genetic component, other modifying factors of biotic and abiotic nature may influence the sensitivity of a great gerbil to infection.The aim of the work was to evaluate the role of genetic and modifying factors in the variation of the sensitivity of the great gerbil to the causative agent of plague. For this, a one-factor analysis of variance was used. The strength of the effect of the intensity of plague epizootics on sensitivity was calculated by the method of Plokhinsky. As a result, it was found that approximately 87 ± 3.9 % of the total variation of the sensitivity sign is due to its genetic component and about 13 % to the share of other factors affecting the characteristic (modifying factors). The conclusion is made that while in studies on the sensitivity of rodents the effect on regulation of the immune response (specific for specific antigens) has not been demonstrated, it is necessary to talk about the general infectious sensitivity of rodents to infections, for example, the causative agent of plague. |
| first_indexed | 2024-03-08T12:17:16Z |
| format | Article |
| id | doaj.art-a984afd7d6434c51bfc6b49d639cd1a7 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:18:25Z |
| publishDate | 2018-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-a984afd7d6434c51bfc6b49d639cd1a72024-03-28T07:49:20ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962018-07-0134273010.29413/ABS.2018-3.4.4637GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTIONV. V. Sutyagin0T. V. Meka-Mechenko1G. G. Kovaleva2A. T. Berdibekov3Taldykorgan Antiplague StationKazakh Scientific Center for Quarantine and zoonotic infections named after M. AikimbayevKazakh Scientific Center for Quarantine and zoonotic infections named after M. AikimbayevTaldykorgan Antiplague StationThe susceptibility of the great gerbil to the causative agent of plague is genetically determined. However, there is not enough information on the involved genes and their effect on this feature in the literature. Although the sensitivity of gerbils to plague microbe may depend on many genes, this feature can be described using a monogenic model of inheritance with one gene. In addition to the genetic component, other modifying factors of biotic and abiotic nature may influence the sensitivity of a great gerbil to infection.The aim of the work was to evaluate the role of genetic and modifying factors in the variation of the sensitivity of the great gerbil to the causative agent of plague. For this, a one-factor analysis of variance was used. The strength of the effect of the intensity of plague epizootics on sensitivity was calculated by the method of Plokhinsky. As a result, it was found that approximately 87 ± 3.9 % of the total variation of the sensitivity sign is due to its genetic component and about 13 % to the share of other factors affecting the characteristic (modifying factors). The conclusion is made that while in studies on the sensitivity of rodents the effect on regulation of the immune response (specific for specific antigens) has not been demonstrated, it is necessary to talk about the general infectious sensitivity of rodents to infections, for example, the causative agent of plague.https://www.actabiomedica.ru/jour/article/view/643great gerbilyersinia pestisinfectious sensitivity |
| spellingShingle | V. V. Sutyagin T. V. Meka-Mechenko G. G. Kovaleva A. T. Berdibekov GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION Acta Biomedica Scientifica great gerbil yersinia pestis infectious sensitivity |
| title | GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION |
| title_full | GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION |
| title_fullStr | GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION |
| title_full_unstemmed | GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION |
| title_short | GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION |
| title_sort | genetic component of great gerbil s susceptibility to plague infection |
| topic | great gerbil yersinia pestis infectious sensitivity |
| url | https://www.actabiomedica.ru/jour/article/view/643 |
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