Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion
ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. H...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043322006173 |
| _version_ | 1817999338829250560 |
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| author | Yuzuna Aoki, MD Masayuki Maeda, MD, PhD Seiya Kishi, MD Ryota Kogue, MD, PhD Fumine Tanaka, MD Maki Umino, MD, PhD Mami Takeoka, MD Ryo Hanaki, MD, PhD Junya Hirayama, MD, PhD Hiroto Yuasa, MD Hiroshi Imai, MD, PhD Masahiro Hirayama, MD, PhD Hajime Sakuma, MD, PhD |
| author_facet | Yuzuna Aoki, MD Masayuki Maeda, MD, PhD Seiya Kishi, MD Ryota Kogue, MD, PhD Fumine Tanaka, MD Maki Umino, MD, PhD Mami Takeoka, MD Ryo Hanaki, MD, PhD Junya Hirayama, MD, PhD Hiroto Yuasa, MD Hiroshi Imai, MD, PhD Masahiro Hirayama, MD, PhD Hajime Sakuma, MD, PhD |
| author_sort | Yuzuna Aoki, MD |
| collection | DOAJ |
| description | ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. However, radiological findings of this disease have not been sufficiently described. Here, we report a case of a 3-year-old boy with ALK-positive histiocytosis with systemic masses that was identified to harbor KIF5B-ALK gene fusion. |
| first_indexed | 2024-04-14T03:07:18Z |
| format | Article |
| id | doaj.art-a985d667288a48b891f6f7a0552f8a0e |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-04-14T03:07:18Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-a985d667288a48b891f6f7a0552f8a0e2022-12-22T02:15:42ZengElsevierRadiology Case Reports1930-04332022-10-01171038673870Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusionYuzuna Aoki, MD0Masayuki Maeda, MD, PhD1Seiya Kishi, MD2Ryota Kogue, MD, PhD3Fumine Tanaka, MD4Maki Umino, MD, PhD5Mami Takeoka, MD6Ryo Hanaki, MD, PhD7Junya Hirayama, MD, PhD8Hiroto Yuasa, MD9Hiroshi Imai, MD, PhD10Masahiro Hirayama, MD, PhD11Hajime Sakuma, MD, PhD12Department of Radiology, Mie University School of Medicine, Tsu, Mie, JapanDepartment of Neuroradiology, Mie University School of Medicine, 2-174 Edobashi, Tsu 514-8507, Mie, Japan; Corresponding author.Department of Radiology, Mie University School of Medicine, Tsu, Mie, JapanDepartment of Radiology, Mie University School of Medicine, Tsu, Mie, JapanDepartment of Radiology, Mie University School of Medicine, Tsu, Mie, JapanDepartment of Radiology, Mie University School of Medicine, Tsu, Mie, JapanDepartment of Pediatrics, Mie University School of Medicine, Tsu, Mie, JapanDepartment of Pediatrics, Mie University School of Medicine, Tsu, Mie, JapanDepartment of Pediatrics, Mie University School of Medicine, Tsu, Mie, JapanPathology Division, Mie University Hospital, Tsu, Mie, JapanPathology Division, Mie University Hospital, Tsu, Mie, JapanDepartment of Pediatrics, Mie University School of Medicine, Tsu, Mie, JapanDepartment of Radiology, Mie University School of Medicine, Tsu, Mie, JapanALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. However, radiological findings of this disease have not been sufficiently described. Here, we report a case of a 3-year-old boy with ALK-positive histiocytosis with systemic masses that was identified to harbor KIF5B-ALK gene fusion.http://www.sciencedirect.com/science/article/pii/S1930043322006173ALK-positive histiocytosisALK gene fusionCTMRIFDG-PET |
| spellingShingle | Yuzuna Aoki, MD Masayuki Maeda, MD, PhD Seiya Kishi, MD Ryota Kogue, MD, PhD Fumine Tanaka, MD Maki Umino, MD, PhD Mami Takeoka, MD Ryo Hanaki, MD, PhD Junya Hirayama, MD, PhD Hiroto Yuasa, MD Hiroshi Imai, MD, PhD Masahiro Hirayama, MD, PhD Hajime Sakuma, MD, PhD Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion Radiology Case Reports ALK-positive histiocytosis ALK gene fusion CT MRI FDG-PET |
| title | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_full | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_fullStr | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_full_unstemmed | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_short | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_sort | central nervous system involvement of systemic alk positive histiocytosis with kif5b alk fusion |
| topic | ALK-positive histiocytosis ALK gene fusion CT MRI FDG-PET |
| url | http://www.sciencedirect.com/science/article/pii/S1930043322006173 |
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