Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer’s Disease and Related Dementias

Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer’s Disease and Related Dementias

Recent findings of diverse populations of prion-like conformers of misfolded tau protein expand the prion concept to Alzheimer’s disease (AD) and monogenic frontotemporal lobar degeneration (FTLD)-MAPT P301L, and suggest that distinct strains of misfolded proteins drive the phenotypes and progressio...

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Bibliographic Details
Main Authors:	Lenka Hromadkova, Mohammad Khursheed Siddiqi, He Liu, Jiri G. Safar
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Series:	Cells
Subjects:	Alzheimer’s disease (AD) frontotemporal lobar degeneration (FTLD) misfolded tau protein conformers prion-like tau strains
Online Access:	https://www.mdpi.com/2073-4409/11/19/2997

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