The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa
The gut microbiota has diverse microbial components, including bacteria, viruses, and fungi. The interaction between gut microbiome components and immune responses has been studied extensively over the last decade. Several studies have reported the potential role of the gut microbiome in maintaining...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Immuno |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-5601/1/4/41 |
| _version_ | 1797503661409042432 |
|---|---|
| author | Takehiro Hirano Hiroshi Nakase |
| author_facet | Takehiro Hirano Hiroshi Nakase |
| author_sort | Takehiro Hirano |
| collection | DOAJ |
| description | The gut microbiota has diverse microbial components, including bacteria, viruses, and fungi. The interaction between gut microbiome components and immune responses has been studied extensively over the last decade. Several studies have reported the potential role of the gut microbiome in maintaining gut homeostasis and the development of disease. The commensal microbiome can preserve the integrity of the mucosal barrier by acting on the host immune system. Contrastingly, dysbiosis-induced inflammation can lead to the initiation and progression of several diseases through inflammatory processes and oxidative stress. In this review, we describe the multifaceted effects of the gut microbiota on several diseases from the perspective of mucosal immunological responses. |
| first_indexed | 2024-03-10T03:53:54Z |
| format | Article |
| id | doaj.art-a9882f900dda4c159f946e5572277d8d |
| institution | Directory Open Access Journal |
| issn | 2673-5601 |
| language | English |
| last_indexed | 2024-03-10T03:53:54Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Immuno |
| spelling | doaj.art-a9882f900dda4c159f946e5572277d8d2023-11-23T08:50:51ZengMDPI AGImmuno2673-56012021-12-011458359410.3390/immuno1040041The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal MucosaTakehiro Hirano0Hiroshi Nakase1Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Minami 1-jo Nishi 16-chome, Chuo-ku, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Minami 1-jo Nishi 16-chome, Chuo-ku, Sapporo 060-8543, JapanThe gut microbiota has diverse microbial components, including bacteria, viruses, and fungi. The interaction between gut microbiome components and immune responses has been studied extensively over the last decade. Several studies have reported the potential role of the gut microbiome in maintaining gut homeostasis and the development of disease. The commensal microbiome can preserve the integrity of the mucosal barrier by acting on the host immune system. Contrastingly, dysbiosis-induced inflammation can lead to the initiation and progression of several diseases through inflammatory processes and oxidative stress. In this review, we describe the multifaceted effects of the gut microbiota on several diseases from the perspective of mucosal immunological responses.https://www.mdpi.com/2673-5601/1/4/41gut microbiotamucosal immunitymetabolitesinflammatory bowel diseasecolon carcinogenesisCOVID-19 |
| spellingShingle | Takehiro Hirano Hiroshi Nakase The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa Immuno gut microbiota mucosal immunity metabolites inflammatory bowel disease colon carcinogenesis COVID-19 |
| title | The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa |
| title_full | The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa |
| title_fullStr | The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa |
| title_full_unstemmed | The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa |
| title_short | The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa |
| title_sort | multifaceted effects of gut microbiota on the immune system of the intestinal mucosa |
| topic | gut microbiota mucosal immunity metabolites inflammatory bowel disease colon carcinogenesis COVID-19 |
| url | https://www.mdpi.com/2673-5601/1/4/41 |
| work_keys_str_mv | AT takehirohirano themultifacetedeffectsofgutmicrobiotaontheimmunesystemoftheintestinalmucosa AT hiroshinakase themultifacetedeffectsofgutmicrobiotaontheimmunesystemoftheintestinalmucosa AT takehirohirano multifacetedeffectsofgutmicrobiotaontheimmunesystemoftheintestinalmucosa AT hiroshinakase multifacetedeffectsofgutmicrobiotaontheimmunesystemoftheintestinalmucosa |