2-Alkyl-Substituted-4-Amino-Thieno[2,3-<i>d</i>]Pyrimidines: Anti-Proliferative Properties to In Vitro Breast Cancer Models

2-Alkyl-Substituted-4-Amino-Thieno[2,3-<i>d</i>]Pyrimidines: Anti-Proliferative Properties to In Vitro Breast Cancer Models

Thienopyrimidines are structural analogs of quinazolines, and the creation of new 2-alkyl derivatives of ethyl 4-aminothienopyrimidine-6-carboxylates for the study of their anti-proliferative properties is of great pharmacological interest. Some 2-alkyl-4-amino-thieno[2,3-<i>d</i>]pyrimi...

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Bibliographic Details
Main Authors: Ivan Iliev, Anelia Mavrova, Denitsa Yancheva, Stefan Dimov, Galya Staneva, Alexandrina Nesheva, Iana Tsoneva, Biliana Nikolova
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Molecules
Subjects:
4-amino-thieno[2,3-<i>d</i>]pyrimidines
synthesis
breast cancer cell lines MCF-10A, MCF-7, MDA-MB-231
anti-proliferative activity
cell cycle analysis
zeta potential
Online Access:https://www.mdpi.com/1420-3049/28/17/6347

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https://www.mdpi.com/1420-3049/28/17/6347

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