Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist
Purpose: We investigated the association between current smoking and clinical outcomes in patients with atrial fibrillation (AF) prescribed vitamin K antagonist (VKA). Methods: We conducted a retrospective study at 71 centers in Japan. The inclusion criterion was taking a VKA for AF. Exclusion crite...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487522000113 |
| _version_ | 1818513507497279488 |
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| author | Hideki Arai Shinichiro Ueda Kazutaka Uchida Fumihiro Sakakibara Norito Kinjo Mari Nezu Takeshi Morimoto |
| author_facet | Hideki Arai Shinichiro Ueda Kazutaka Uchida Fumihiro Sakakibara Norito Kinjo Mari Nezu Takeshi Morimoto |
| author_sort | Hideki Arai |
| collection | DOAJ |
| description | Purpose: We investigated the association between current smoking and clinical outcomes in patients with atrial fibrillation (AF) prescribed vitamin K antagonist (VKA). Methods: We conducted a retrospective study at 71 centers in Japan. The inclusion criterion was taking a VKA for AF. Exclusion criteria were mechanical heart valves or history of pulmonary thrombosis or deep vein thrombosis. Consecutive patients were registered in February 2013 and followed until February 2017. The primary outcomes included ischemic events and major bleedings. The secondary outcomes were ischemic stroke, hemorrhagic stroke, and all-cause mortality. Results: A total of 7826 patients were included, with a mean age of 73 years; 5274 (67%) were men. The adjusted hazard ratios (HRs; 95% confidence intervals [CIs]) of current smokers relative to non–current smokers for ischemic events and major bleedings were 1.64 (1.05–2.57) and 1.09 (0.72–1.65), respectively. The adjusted HRs (95% CIs) of current smokers relative to non–current smokers for ischemic stroke, hemorrhagic stroke, and all-cause mortality were 1.65 (1.03–2.64), 0.52 (0.12–2.15), and 1.26 (0.83–1.92), respectively. Conclusions: There were significant associations between current smoking and ischemic events or ischemic stroke in patients with AF on VKA. |
| first_indexed | 2024-12-11T00:02:26Z |
| format | Article |
| id | doaj.art-a988c0c9c03a49a7874bc587e4298e31 |
| institution | Directory Open Access Journal |
| issn | 2772-4875 |
| language | English |
| last_indexed | 2024-12-11T00:02:26Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj.art-a988c0c9c03a49a7874bc587e4298e312022-12-22T01:28:25ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752022-09-0114200135Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonistHideki Arai0Shinichiro Ueda1Kazutaka Uchida2Fumihiro Sakakibara3Norito Kinjo4Mari Nezu5Takeshi Morimoto6Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan; Department of Internal Medicine, Toyonaka Heisei Hospital, Toyonaka, JapanDepartment of Clinical Pharmacology and Therapeutics, University of the Ryukyus, Okinawa, JapanDepartment of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan; Department of Neurosurgery, Hyogo College of Medicine, Nishinomiya, JapanDepartment of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan; Department of Neurosurgery, Hyogo College of Medicine, Nishinomiya, JapanDepartment of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan; Department of Neurosurgery, Hyogo College of Medicine, Nishinomiya, JapanDepartment of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, JapanDepartment of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan; Corresponding author. Professor of Medicine, Department of Clinical Epidemiology, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.Purpose: We investigated the association between current smoking and clinical outcomes in patients with atrial fibrillation (AF) prescribed vitamin K antagonist (VKA). Methods: We conducted a retrospective study at 71 centers in Japan. The inclusion criterion was taking a VKA for AF. Exclusion criteria were mechanical heart valves or history of pulmonary thrombosis or deep vein thrombosis. Consecutive patients were registered in February 2013 and followed until February 2017. The primary outcomes included ischemic events and major bleedings. The secondary outcomes were ischemic stroke, hemorrhagic stroke, and all-cause mortality. Results: A total of 7826 patients were included, with a mean age of 73 years; 5274 (67%) were men. The adjusted hazard ratios (HRs; 95% confidence intervals [CIs]) of current smokers relative to non–current smokers for ischemic events and major bleedings were 1.64 (1.05–2.57) and 1.09 (0.72–1.65), respectively. The adjusted HRs (95% CIs) of current smokers relative to non–current smokers for ischemic stroke, hemorrhagic stroke, and all-cause mortality were 1.65 (1.03–2.64), 0.52 (0.12–2.15), and 1.26 (0.83–1.92), respectively. Conclusions: There were significant associations between current smoking and ischemic events or ischemic stroke in patients with AF on VKA.http://www.sciencedirect.com/science/article/pii/S2772487522000113Atrial fibrillationIschemic eventRegistrySmokingVitamin K antagonist |
| spellingShingle | Hideki Arai Shinichiro Ueda Kazutaka Uchida Fumihiro Sakakibara Norito Kinjo Mari Nezu Takeshi Morimoto Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist International Journal of Cardiology. Cardiovascular Risk and Prevention Atrial fibrillation Ischemic event Registry Smoking Vitamin K antagonist |
| title | Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist |
| title_full | Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist |
| title_fullStr | Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist |
| title_full_unstemmed | Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist |
| title_short | Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist |
| title_sort | effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin k antagonist |
| topic | Atrial fibrillation Ischemic event Registry Smoking Vitamin K antagonist |
| url | http://www.sciencedirect.com/science/article/pii/S2772487522000113 |
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