| Summary: | <i>Helicobacter pylori</i> is an established cause of many gastrointestinal pathologies including peptic ulcer disease, gastritis, and gastric cancer. It is an entity that affects the global population, and its true nature has only been known since the 1980s. Although there is much known about <i>H. pylori</i> including its pathophysiology, detection, and eradication, resistance to current therapy models is common. This is problematic because untreated or inadequately treated <i>H. pylori</i> increases morbidity and mortality related to gastric cancer and peptic ulcer disease among others. In order to improve the treatment and reduce resistance, there is significant ongoing research identifying new detection and eradication methods for <i>H. pylori</i>. This review aims to highlight what has already been established regarding <i>H. pylori</i>’s epidemiology, pathophysiology, detection, and treatment as well as the most current and novel research involving detection and treatment of <i>H. pylori</i>.
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