A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy and safety in the disorder. Unexpectedly, Marfan mice treated with CCBs show accelerated aneurysm expansion, rupture, and p...

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Bibliographic Details
Main Authors: Jefferson J Doyle, Alexander J Doyle, Nicole K Wilson, Jennifer P Habashi, Djahida Bedja, Ryan E Whitworth, Mark E Lindsay, Florian Schoenhoff, Loretha Myers, Nick Huso, Suha Bachir, Oliver Squires, Benjamin Rusholme, Hamid Ehsan, David Huso, Craig J Thomas, Mark J Caulfield, Jennifer E Van Eyk, Daniel P Judge, Harry C Dietz, GenTAC Registry Consortium, MIBAVA Leducq Consortium
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
aortic aneurysm
Marfan syndrome
protein kinase C
ERK
calcium channel blocker
Amlodipine
Online Access:https://elifesciences.org/articles/08648

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