Spatial Distribution and Burden of Emerging Arboviruses in French Guiana
Despite the health, social and economic impact of arboviruses in French Guiana, very little is known about the extent to which infection burden is shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June to October 2017. All serum samples were...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/7/1299 |
| _version_ | 1827686742017179648 |
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| author | Sarah Bailly Dominique Rousset Camille Fritzell Nathanaël Hozé Sarrah Ben Achour Léna Berthelot Antoine Enfissi Jessica Vanhomwegen Henrik Salje Sandrine Fernandes-Pellerin Mona Saout Anne Lavergne Jean-Claude Manuguerra Jean-François Carod Félix Djossou Simon Cauchemez Claude Flamand |
| author_facet | Sarah Bailly Dominique Rousset Camille Fritzell Nathanaël Hozé Sarrah Ben Achour Léna Berthelot Antoine Enfissi Jessica Vanhomwegen Henrik Salje Sandrine Fernandes-Pellerin Mona Saout Anne Lavergne Jean-Claude Manuguerra Jean-François Carod Félix Djossou Simon Cauchemez Claude Flamand |
| author_sort | Sarah Bailly |
| collection | DOAJ |
| description | Despite the health, social and economic impact of arboviruses in French Guiana, very little is known about the extent to which infection burden is shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June to October 2017. All serum samples were tested for IgG antibodies against DENV, CHIKV, ZIKV and MAYV using a recombinant antigen-based microsphere immunoassay with a subset further evaluated through anti-ZIKV microneutralization tests. The overall DENV seroprevalence was estimated at 73.1% (70.6–75.4) in the whole territory with estimations by serotype at 68.9% for DENV-1, 38.8% for DENV-2, 42.3% for DENV-3, and 56.1% for DENV-4. The overall seroprevalence of CHIKV, ZIKV and MAYV antibodies was 20.3% (17.7–23.1), 23.3% (20.9–25.9) and 3.3% (2.7–4.1), respectively. We provide a consistent overview of the burden of emerging arboviruses in French Guiana, with useful findings for risk mapping, future prevention and control programs. The majority of the population remains susceptible to CHIKV and ZIKV, which could potentially facilitate the risk of further re-emergences. Our results underscore the need to strengthen MAYV surveillance in order to rapidly detect any substantial changes in MAYV circulation patterns. |
| first_indexed | 2024-03-10T09:21:00Z |
| format | Article |
| id | doaj.art-a98d3bcc836044d791bd9bc9f9eaa37a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T09:21:00Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a98d3bcc836044d791bd9bc9f9eaa37a2023-11-22T05:13:49ZengMDPI AGViruses1999-49152021-07-01137129910.3390/v13071299Spatial Distribution and Burden of Emerging Arboviruses in French GuianaSarah Bailly0Dominique Rousset1Camille Fritzell2Nathanaël Hozé3Sarrah Ben Achour4Léna Berthelot5Antoine Enfissi6Jessica Vanhomwegen7Henrik Salje8Sandrine Fernandes-Pellerin9Mona Saout10Anne Lavergne11Jean-Claude Manuguerra12Jean-François Carod13Félix Djossou14Simon Cauchemez15Claude Flamand16Epidemiology Unit, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaArbovirus National Reference Center, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaEpidemiology Unit, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaMathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, 75015 Paris, FranceArbovirus National Reference Center, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaArbovirus National Reference Center, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaArbovirus National Reference Center, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaEnvironment and Infectious Risks Unit, Institut Pasteur, 75015 Paris, FranceMathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, 75015 Paris, FranceClinical Coordination of Translational Research Center, Institut Pasteur, 75015 Paris, FranceEpidemiology Unit, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaArbovirus National Reference Center, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaEnvironment and Infectious Risks Unit, Institut Pasteur, 75015 Paris, FranceMedical Laboratory, Centre Hospitalier de l’Ouest Guyanais, 97320 Saint-Laurent du Maroni, French GuianaInfectious and Tropical Diseases Unit, Centre Hospitalier Andrée Rosemon, 97300 Cayenne, French GuianaMathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, 75015 Paris, FranceEpidemiology Unit, Institut Pasteur in French Guiana, 97300 Cayenne, French GuianaDespite the health, social and economic impact of arboviruses in French Guiana, very little is known about the extent to which infection burden is shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June to October 2017. All serum samples were tested for IgG antibodies against DENV, CHIKV, ZIKV and MAYV using a recombinant antigen-based microsphere immunoassay with a subset further evaluated through anti-ZIKV microneutralization tests. The overall DENV seroprevalence was estimated at 73.1% (70.6–75.4) in the whole territory with estimations by serotype at 68.9% for DENV-1, 38.8% for DENV-2, 42.3% for DENV-3, and 56.1% for DENV-4. The overall seroprevalence of CHIKV, ZIKV and MAYV antibodies was 20.3% (17.7–23.1), 23.3% (20.9–25.9) and 3.3% (2.7–4.1), respectively. We provide a consistent overview of the burden of emerging arboviruses in French Guiana, with useful findings for risk mapping, future prevention and control programs. The majority of the population remains susceptible to CHIKV and ZIKV, which could potentially facilitate the risk of further re-emergences. Our results underscore the need to strengthen MAYV surveillance in order to rapidly detect any substantial changes in MAYV circulation patterns.https://www.mdpi.com/1999-4915/13/7/1299arbovirusesDengueZikaChikungunyaMayaroprevalence studies |
| spellingShingle | Sarah Bailly Dominique Rousset Camille Fritzell Nathanaël Hozé Sarrah Ben Achour Léna Berthelot Antoine Enfissi Jessica Vanhomwegen Henrik Salje Sandrine Fernandes-Pellerin Mona Saout Anne Lavergne Jean-Claude Manuguerra Jean-François Carod Félix Djossou Simon Cauchemez Claude Flamand Spatial Distribution and Burden of Emerging Arboviruses in French Guiana Viruses arboviruses Dengue Zika Chikungunya Mayaro prevalence studies |
| title | Spatial Distribution and Burden of Emerging Arboviruses in French Guiana |
| title_full | Spatial Distribution and Burden of Emerging Arboviruses in French Guiana |
| title_fullStr | Spatial Distribution and Burden of Emerging Arboviruses in French Guiana |
| title_full_unstemmed | Spatial Distribution and Burden of Emerging Arboviruses in French Guiana |
| title_short | Spatial Distribution and Burden of Emerging Arboviruses in French Guiana |
| title_sort | spatial distribution and burden of emerging arboviruses in french guiana |
| topic | arboviruses Dengue Zika Chikungunya Mayaro prevalence studies |
| url | https://www.mdpi.com/1999-4915/13/7/1299 |
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