Recent Advances in the Optimization of Anti-TNF Treatment in Patients with Inflammatory Bowel Disease
Despite the evolution in inflammatory bowel disease (IBD) management during the last 20 years owing to the advent of new advanced therapies, anti-TNF agents still remain the cornerstone of therapy for both Crohn’s disease and ulcerative colitis. However, this does not only secure favorable outcomes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/7/2452 |
| _version_ | 1797607667448938496 |
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| author | Eleni Orfanoudaki Kalliopi Foteinogiannopoulou Eirini Theodoraki Ioannis E. Koutroubakis |
| author_facet | Eleni Orfanoudaki Kalliopi Foteinogiannopoulou Eirini Theodoraki Ioannis E. Koutroubakis |
| author_sort | Eleni Orfanoudaki |
| collection | DOAJ |
| description | Despite the evolution in inflammatory bowel disease (IBD) management during the last 20 years owing to the advent of new advanced therapies, anti-TNF agents still remain the cornerstone of therapy for both Crohn’s disease and ulcerative colitis. However, this does not only secure favorable outcomes for patients considering the progressive disease character and the high likelihood of primary or secondary loss of response. Therefore, trying to reach a better treatment approach and maximize the benefits anti-TNF agents offer, optimization strategies should be examined. It has been indicated that optimizing treatment with anti-TNF enhances drug efficacy and has been associated with improved disease outcomes and a complication-free disease course. From this perspective, we aim to provide an overview of currently available data and recent advances in the practices of anti-TNF treatment optimization. Special focus has been given to the role of therapeutic drug monitoring (TDM), as well as the utility of combining anti-TNF with an immunomodulator and the treat-to-target approach. |
| first_indexed | 2024-03-11T05:34:04Z |
| format | Article |
| id | doaj.art-a98d68c962b44e9fa4c010b0f19a4e92 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T05:34:04Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a98d68c962b44e9fa4c010b0f19a4e922023-11-17T16:57:20ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01127245210.3390/jcm12072452Recent Advances in the Optimization of Anti-TNF Treatment in Patients with Inflammatory Bowel DiseaseEleni Orfanoudaki0Kalliopi Foteinogiannopoulou1Eirini Theodoraki2Ioannis E. Koutroubakis3Department of Gastroenterology, University Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, GreeceDepartment of Gastroenterology, University Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, GreeceDepartment of Gastroenterology, University Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, GreeceDepartment of Gastroenterology, University Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, GreeceDespite the evolution in inflammatory bowel disease (IBD) management during the last 20 years owing to the advent of new advanced therapies, anti-TNF agents still remain the cornerstone of therapy for both Crohn’s disease and ulcerative colitis. However, this does not only secure favorable outcomes for patients considering the progressive disease character and the high likelihood of primary or secondary loss of response. Therefore, trying to reach a better treatment approach and maximize the benefits anti-TNF agents offer, optimization strategies should be examined. It has been indicated that optimizing treatment with anti-TNF enhances drug efficacy and has been associated with improved disease outcomes and a complication-free disease course. From this perspective, we aim to provide an overview of currently available data and recent advances in the practices of anti-TNF treatment optimization. Special focus has been given to the role of therapeutic drug monitoring (TDM), as well as the utility of combining anti-TNF with an immunomodulator and the treat-to-target approach.https://www.mdpi.com/2077-0383/12/7/2452biologicsCrohn’s diseaseimmunomodulatorstherapeutic drug monitoringulcerative colitis |
| spellingShingle | Eleni Orfanoudaki Kalliopi Foteinogiannopoulou Eirini Theodoraki Ioannis E. Koutroubakis Recent Advances in the Optimization of Anti-TNF Treatment in Patients with Inflammatory Bowel Disease Journal of Clinical Medicine biologics Crohn’s disease immunomodulators therapeutic drug monitoring ulcerative colitis |
| title | Recent Advances in the Optimization of Anti-TNF Treatment in Patients with Inflammatory Bowel Disease |
| title_full | Recent Advances in the Optimization of Anti-TNF Treatment in Patients with Inflammatory Bowel Disease |
| title_fullStr | Recent Advances in the Optimization of Anti-TNF Treatment in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Recent Advances in the Optimization of Anti-TNF Treatment in Patients with Inflammatory Bowel Disease |
| title_short | Recent Advances in the Optimization of Anti-TNF Treatment in Patients with Inflammatory Bowel Disease |
| title_sort | recent advances in the optimization of anti tnf treatment in patients with inflammatory bowel disease |
| topic | biologics Crohn’s disease immunomodulators therapeutic drug monitoring ulcerative colitis |
| url | https://www.mdpi.com/2077-0383/12/7/2452 |
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