Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications
Nanocelluloses (NCs), with their remarkable characteristics, have proven to be one of the most promising “green” materials of our times and have received special attention from researchers in nanomaterials. A diversity of new functional materials with a wide range of biomedical applications has been...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/8/1125 |
| _version_ | 1797522447115747328 |
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| author | Raluca Nicu Florin Ciolacu Diana E. Ciolacu |
| author_facet | Raluca Nicu Florin Ciolacu Diana E. Ciolacu |
| author_sort | Raluca Nicu |
| collection | DOAJ |
| description | Nanocelluloses (NCs), with their remarkable characteristics, have proven to be one of the most promising “green” materials of our times and have received special attention from researchers in nanomaterials. A diversity of new functional materials with a wide range of biomedical applications has been designed based on the most desirable properties of NCs, such as biocompatibility, biodegradability, and their special physicochemical properties. In this context and under the pressure of rapid development of this field, it is imperative to synthesize the successes and the new requirements in a comprehensive review. The first part of this work provides a brief review of the characteristics of the NCs (cellulose nanocrystals—CNC, cellulose nanofibrils—CNF, and bacterial nanocellulose—BNC), as well as of the main functional materials based on NCs (hydrogels, nanogels, and nanocomposites). The second part presents an extensive review of research over the past five years on promising pharmaceutical and medical applications of nanocellulose-based materials, which have been discussed in three important areas: drug-delivery systems, materials for wound-healing applications, as well as tissue engineering. Finally, an in-depth assessment of the in vitro and in vivo cytotoxicity of NCs-based materials, as well as the challenges related to their biodegradability, is performed. |
| first_indexed | 2024-03-10T08:29:30Z |
| format | Article |
| id | doaj.art-a98db43b5c2544e0abb13b7373daf793 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T08:29:30Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a98db43b5c2544e0abb13b7373daf7932023-11-22T09:12:50ZengMDPI AGPharmaceutics1999-49232021-07-01138112510.3390/pharmaceutics13081125Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical ApplicationsRaluca Nicu0Florin Ciolacu1Diana E. Ciolacu2Department of Natural Polymers, Bioactive and Biocompatible Materials, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaDepartment of Natural and Synthetic Polymers, “Gheorghe Asachi” Technical University of Iasi, 700050 Iasi, RomaniaDepartment of Natural Polymers, Bioactive and Biocompatible Materials, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaNanocelluloses (NCs), with their remarkable characteristics, have proven to be one of the most promising “green” materials of our times and have received special attention from researchers in nanomaterials. A diversity of new functional materials with a wide range of biomedical applications has been designed based on the most desirable properties of NCs, such as biocompatibility, biodegradability, and their special physicochemical properties. In this context and under the pressure of rapid development of this field, it is imperative to synthesize the successes and the new requirements in a comprehensive review. The first part of this work provides a brief review of the characteristics of the NCs (cellulose nanocrystals—CNC, cellulose nanofibrils—CNF, and bacterial nanocellulose—BNC), as well as of the main functional materials based on NCs (hydrogels, nanogels, and nanocomposites). The second part presents an extensive review of research over the past five years on promising pharmaceutical and medical applications of nanocellulose-based materials, which have been discussed in three important areas: drug-delivery systems, materials for wound-healing applications, as well as tissue engineering. Finally, an in-depth assessment of the in vitro and in vivo cytotoxicity of NCs-based materials, as well as the challenges related to their biodegradability, is performed.https://www.mdpi.com/1999-4923/13/8/1125nanocellulosenanocrystalline cellulosenanofibrillated cellulosebacterial cellulosehydrogelsnanogels |
| spellingShingle | Raluca Nicu Florin Ciolacu Diana E. Ciolacu Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications Pharmaceutics nanocellulose nanocrystalline cellulose nanofibrillated cellulose bacterial cellulose hydrogels nanogels |
| title | Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications |
| title_full | Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications |
| title_fullStr | Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications |
| title_full_unstemmed | Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications |
| title_short | Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications |
| title_sort | advanced functional materials based on nanocellulose for pharmaceutical medical applications |
| topic | nanocellulose nanocrystalline cellulose nanofibrillated cellulose bacterial cellulose hydrogels nanogels |
| url | https://www.mdpi.com/1999-4923/13/8/1125 |
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