The integrated stress response in budding yeast lifespan extension
Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion. The ultimate goal of aging research is to develop therape...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2017-10-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/the-integrated-stress-response-in-budding-yeast-lifespan-extension/ |
| _version_ | 1811284560708632576 |
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| author | Spike D.L. Postnikoff Jay E. Johnson Jessica K. Tyler |
| author_facet | Spike D.L. Postnikoff Jay E. Johnson Jessica K. Tyler |
| author_sort | Spike D.L. Postnikoff |
| collection | DOAJ |
| description | Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion. The ultimate goal of aging research is to develop therapeutic means to extend human lifespan, while reducing susceptibility to many age-related diseases including cancer, as well as metabolic, cardiovascular and neurodegenerative disorders. However, this first requires elucidation of the causes of aging, which has been greatly facilitated by the use of model organisms. In particular, the budding yeast Saccharomyces cerevisiae has been invaluable in the identification of conserved molecular and cellular determinants of aging and for the development of approaches to manipulate these aging determinants to extend lifespan. Strikingly, where examined, virtually all means to experimentally extend lifespan result in the induction of cellular stress responses. This review describes growing evidence in yeast that activation of the integrated stress response contributes significantly to lifespan extension. These findings demonstrate that yeast remains a powerful model system for elucidating conserved mechanisms to achieve lifespan extension that are likely to drive therapeutic approaches to extend human lifespan and healthspan. |
| first_indexed | 2024-04-13T02:30:35Z |
| format | Article |
| id | doaj.art-a98dd079388a4267a877ba81afdea0c6 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-04-13T02:30:35Z |
| publishDate | 2017-10-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-a98dd079388a4267a877ba81afdea0c62022-12-22T03:06:35ZengShared Science Publishers OGMicrobial Cell2311-26382017-10-0141136837510.15698/mic2017.11.597The integrated stress response in budding yeast lifespan extensionSpike D.L. Postnikoff0Jay E. Johnson1Jessica K. Tyler2Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065.Orentreich Foundation for the Advancement of Science, Cold Spring, NY.Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065.Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion. The ultimate goal of aging research is to develop therapeutic means to extend human lifespan, while reducing susceptibility to many age-related diseases including cancer, as well as metabolic, cardiovascular and neurodegenerative disorders. However, this first requires elucidation of the causes of aging, which has been greatly facilitated by the use of model organisms. In particular, the budding yeast Saccharomyces cerevisiae has been invaluable in the identification of conserved molecular and cellular determinants of aging and for the development of approaches to manipulate these aging determinants to extend lifespan. Strikingly, where examined, virtually all means to experimentally extend lifespan result in the induction of cellular stress responses. This review describes growing evidence in yeast that activation of the integrated stress response contributes significantly to lifespan extension. These findings demonstrate that yeast remains a powerful model system for elucidating conserved mechanisms to achieve lifespan extension that are likely to drive therapeutic approaches to extend human lifespan and healthspan.http://microbialcell.com/researcharticles/the-integrated-stress-response-in-budding-yeast-lifespan-extension/replicative lifespanchronological lifespanbudding yeastintegrated stress responseautophagy |
| spellingShingle | Spike D.L. Postnikoff Jay E. Johnson Jessica K. Tyler The integrated stress response in budding yeast lifespan extension Microbial Cell replicative lifespan chronological lifespan budding yeast integrated stress response autophagy |
| title | The integrated stress response in budding yeast lifespan extension |
| title_full | The integrated stress response in budding yeast lifespan extension |
| title_fullStr | The integrated stress response in budding yeast lifespan extension |
| title_full_unstemmed | The integrated stress response in budding yeast lifespan extension |
| title_short | The integrated stress response in budding yeast lifespan extension |
| title_sort | integrated stress response in budding yeast lifespan extension |
| topic | replicative lifespan chronological lifespan budding yeast integrated stress response autophagy |
| url | http://microbialcell.com/researcharticles/the-integrated-stress-response-in-budding-yeast-lifespan-extension/ |
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