The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget’s Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre
Background: Extramammary Paget’s disease (EMPD) is a rare malignant cutaneous tumour that is commonly located in anogenital regions. The diagnosis of the disease is always delayed, and treatment is usually troublesome. This study aims to summarise the clinicopathological characteristics and the risk...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/2/582 |
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| author | Zeyang Chen Zining Liu Shaorong Pan Jin Liu Shuai Zuo Pengyuan Wang |
| author_facet | Zeyang Chen Zining Liu Shaorong Pan Jin Liu Shuai Zuo Pengyuan Wang |
| author_sort | Zeyang Chen |
| collection | DOAJ |
| description | Background: Extramammary Paget’s disease (EMPD) is a rare malignant cutaneous tumour that is commonly located in anogenital regions. The diagnosis of the disease is always delayed, and treatment is usually troublesome. This study aims to summarise the clinicopathological characteristics and the risk factors of prognosis for EMPD in anogenital regions, potentially providing evidence for the diagnosis and treatment of anogenital EMPD. Methods: 688 patients were sourced from the Surveillance, Epidemiology and End Results (SEER) program between 1992 and 2021. In total, 176 participants from our centre from between 2011 and 2021 were included to investigate the characteristics and prognosis for EMPD in anogenital regions. Results: From the SEER program data, patient age of 65 years or older, metastasis of lymph nodes, Spanish-Hispanic-Latino race, diameter exceeding 10cm and lesions located anally were revealed as independent risk factors for shorter cancer-specific survival (CSS). However, the data from our centre highlighted that metastasis of lymph nodes and tumours extending through the epidermis are independent risk factors of shortened progression-free survival (PFS) and CSS of anogenital EMPD. Conclusion: This synthesised study revealed that some characteristics are regarded as risk factors for poor clinical prognosis, which have potential value in formulating more normative and effective strategies for patients with EMPD in anogenital regions. |
| first_indexed | 2024-03-09T12:12:02Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:12:02Z |
| publishDate | 2023-01-01 |
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| spelling | doaj.art-a98e8fea9b2e4fda80465b7a8e86ab0f2023-11-30T22:51:55ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112258210.3390/jcm12020582The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget’s Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our CentreZeyang Chen0Zining Liu1Shaorong Pan2Jin Liu3Shuai Zuo4Pengyuan Wang5Department of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Xicheng District, Beijing 100034, ChinaDepartment of Gynecology Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Xicheng District, Beijing 100034, ChinaDepartment of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Xicheng District, Beijing 100034, ChinaDepartment of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Xicheng District, Beijing 100034, ChinaDepartment of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Xicheng District, Beijing 100034, ChinaBackground: Extramammary Paget’s disease (EMPD) is a rare malignant cutaneous tumour that is commonly located in anogenital regions. The diagnosis of the disease is always delayed, and treatment is usually troublesome. This study aims to summarise the clinicopathological characteristics and the risk factors of prognosis for EMPD in anogenital regions, potentially providing evidence for the diagnosis and treatment of anogenital EMPD. Methods: 688 patients were sourced from the Surveillance, Epidemiology and End Results (SEER) program between 1992 and 2021. In total, 176 participants from our centre from between 2011 and 2021 were included to investigate the characteristics and prognosis for EMPD in anogenital regions. Results: From the SEER program data, patient age of 65 years or older, metastasis of lymph nodes, Spanish-Hispanic-Latino race, diameter exceeding 10cm and lesions located anally were revealed as independent risk factors for shorter cancer-specific survival (CSS). However, the data from our centre highlighted that metastasis of lymph nodes and tumours extending through the epidermis are independent risk factors of shortened progression-free survival (PFS) and CSS of anogenital EMPD. Conclusion: This synthesised study revealed that some characteristics are regarded as risk factors for poor clinical prognosis, which have potential value in formulating more normative and effective strategies for patients with EMPD in anogenital regions.https://www.mdpi.com/2077-0383/12/2/582extramammary Paget’s disease (EMPD)SEER databaseanogenital regionsprognosisrecurrence |
| spellingShingle | Zeyang Chen Zining Liu Shaorong Pan Jin Liu Shuai Zuo Pengyuan Wang The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget’s Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre Journal of Clinical Medicine extramammary Paget’s disease (EMPD) SEER database anogenital regions prognosis recurrence |
| title | The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget’s Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre |
| title_full | The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget’s Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre |
| title_fullStr | The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget’s Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre |
| title_full_unstemmed | The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget’s Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre |
| title_short | The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget’s Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre |
| title_sort | clinical characteristics and prognostic factors of primary extramammary paget s disease treated with surgery in anogenital regions a large population study from the seer database and our centre |
| topic | extramammary Paget’s disease (EMPD) SEER database anogenital regions prognosis recurrence |
| url | https://www.mdpi.com/2077-0383/12/2/582 |
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