Docking Simulation of the Binding Interactions of Saxitoxin Analogs Produced by the Marine Dinoflagellate Gymnodinium catenatum to the Voltage-Gated Sodium Channel Nav1.4

Docking Simulation of the Binding Interactions of Saxitoxin Analogs Produced by the Marine Dinoflagellate Gymnodinium catenatum to the Voltage-Gated Sodium Channel Nav1.4

Saxitoxin (STX) and its analogs are paralytic alkaloid neurotoxins that block the voltage-gated sodium channel pore (Nav), impeding passage of Na+ ions into the intracellular space, and thereby preventing the action potential in the peripheral nervous system and skeletal muscle. The marine dinoflage...

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Bibliographic Details
Main Authors: Lorena M. Durán-Riveroll, Allan D. Cembella, Christine J. Band-Schmidt, José J. Bustillos-Guzmán, José Correa-Basurto
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Toxins
Subjects:
voltage-gated sodium channel
benzoyl saxitoxin analogs
molecular docking
binding affinity
Online Access:http://www.mdpi.com/2072-6651/8/5/129

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