Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington’s Disease Mice

Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington’s Disease Mice

Huntington’s disease (HD) is a heritable neurological disorder that affects cognitive and motor performance in patients carrying the mutated huntingtin (HTT) gene. In mouse models of HD, previous reports showed a significant increase in spontaneous GABAA receptor-mediated synaptic activity in striat...

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Bibliographic Details
Main Authors: Sandra M. Holley, Laurie Galvan, Talia Kamdjou, Ashley Dong, Michael S. Levine, Carlos Cepeda
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
striatum
Huntington’s disease (HD)
GABA interneurons
CB1 receptors
electrophysiology
optogenetics
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2019.00014/full

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