Delayed β-cell response and glucose intolerance in young women with Turner syndrome
<p>Abstract</p> <p>Background</p> <p>To investigate glucose homeostasis in detail in Turner syndrome (TS), where impaired glucose tolerance (IGT) and type 2 diabetes are frequent.</p> <p>Methods</p> <p>Cross sectional study of women with Turner s...
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| Format: | Article |
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BMC
2011-03-01
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| Series: | BMC Endocrine Disorders |
| Online Access: | http://www.biomedcentral.com/1472-6823/11/6 |
| _version_ | 1818199431004028928 |
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| author | Schmitz Ole Christiansen Jens S Juhl Claus B Holst Jens J Hjerrild Britta E Gravholt Claus H |
| author_facet | Schmitz Ole Christiansen Jens S Juhl Claus B Holst Jens J Hjerrild Britta E Gravholt Claus H |
| author_sort | Schmitz Ole |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To investigate glucose homeostasis in detail in Turner syndrome (TS), where impaired glucose tolerance (IGT) and type 2 diabetes are frequent.</p> <p>Methods</p> <p>Cross sectional study of women with Turner syndrome (TS)(n = 13) and age and body mass index matched controls (C) (n = 13), evaluated by glucose tolerance (oral and intravenous glucose tolerance test (OGTT and IVGTT)), insulin sensitivity (hyperinsulinemic, euglycemic clamp), beta-cell function (hyperglycaemic clamp, arginine and GLP-1 stimulation) and insulin pulsatility.</p> <p>Results</p> <p>Fasting glucose and insulin levels were similar. Higher glucose responses was seen in TS during OGTT and IVGTT, persisting after correction for body weight or muscle mass, while insulin responses were similar in TS and C, despite the higher glucose level in TS, leading to an insufficient increase in insulin response during dynamic testing. Insulin sensitivity was comparable in the two groups (TS vs. control: 8.6 ± 1.8 vs. 8.9 ± 1.8 mg/kg*30 min; p = 0.6), and the insulin responses to dynamic β-cell function tests were similar. Insulin secretion patterns examined by deconvolution analysis, approximate entropy, spectral analysis and autocorrelation analysis were similar. In addition we found low IGF-I, higher levels of cortisol and norepinephrine and an increased waist-hip ratio in TS.</p> <p>Conclusions</p> <p>Young normal weight TS women show significant glucose intolerance in spite of normal insulin secretion during hyperglycaemic clamping and normal insulin sensitivity. We recommend regularly testing for diabetes in TS.</p> <p>Trial Registration</p> <p>Registered with <url>http://clinicaltrials.com</url>, ID nr: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00419107">NCT00419107</a></p> |
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| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-12T02:21:39Z |
| publishDate | 2011-03-01 |
| publisher | BMC |
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| series | BMC Endocrine Disorders |
| spelling | doaj.art-a991383a1d7a4560a0dc0d4836cac8e32022-12-22T00:41:39ZengBMCBMC Endocrine Disorders1472-68232011-03-01111610.1186/1472-6823-11-6Delayed β-cell response and glucose intolerance in young women with Turner syndromeSchmitz OleChristiansen Jens SJuhl Claus BHolst Jens JHjerrild Britta EGravholt Claus H<p>Abstract</p> <p>Background</p> <p>To investigate glucose homeostasis in detail in Turner syndrome (TS), where impaired glucose tolerance (IGT) and type 2 diabetes are frequent.</p> <p>Methods</p> <p>Cross sectional study of women with Turner syndrome (TS)(n = 13) and age and body mass index matched controls (C) (n = 13), evaluated by glucose tolerance (oral and intravenous glucose tolerance test (OGTT and IVGTT)), insulin sensitivity (hyperinsulinemic, euglycemic clamp), beta-cell function (hyperglycaemic clamp, arginine and GLP-1 stimulation) and insulin pulsatility.</p> <p>Results</p> <p>Fasting glucose and insulin levels were similar. Higher glucose responses was seen in TS during OGTT and IVGTT, persisting after correction for body weight or muscle mass, while insulin responses were similar in TS and C, despite the higher glucose level in TS, leading to an insufficient increase in insulin response during dynamic testing. Insulin sensitivity was comparable in the two groups (TS vs. control: 8.6 ± 1.8 vs. 8.9 ± 1.8 mg/kg*30 min; p = 0.6), and the insulin responses to dynamic β-cell function tests were similar. Insulin secretion patterns examined by deconvolution analysis, approximate entropy, spectral analysis and autocorrelation analysis were similar. In addition we found low IGF-I, higher levels of cortisol and norepinephrine and an increased waist-hip ratio in TS.</p> <p>Conclusions</p> <p>Young normal weight TS women show significant glucose intolerance in spite of normal insulin secretion during hyperglycaemic clamping and normal insulin sensitivity. We recommend regularly testing for diabetes in TS.</p> <p>Trial Registration</p> <p>Registered with <url>http://clinicaltrials.com</url>, ID nr: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00419107">NCT00419107</a></p>http://www.biomedcentral.com/1472-6823/11/6 |
| spellingShingle | Schmitz Ole Christiansen Jens S Juhl Claus B Holst Jens J Hjerrild Britta E Gravholt Claus H Delayed β-cell response and glucose intolerance in young women with Turner syndrome BMC Endocrine Disorders |
| title | Delayed β-cell response and glucose intolerance in young women with Turner syndrome |
| title_full | Delayed β-cell response and glucose intolerance in young women with Turner syndrome |
| title_fullStr | Delayed β-cell response and glucose intolerance in young women with Turner syndrome |
| title_full_unstemmed | Delayed β-cell response and glucose intolerance in young women with Turner syndrome |
| title_short | Delayed β-cell response and glucose intolerance in young women with Turner syndrome |
| title_sort | delayed β cell response and glucose intolerance in young women with turner syndrome |
| url | http://www.biomedcentral.com/1472-6823/11/6 |
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