mRNA vaccines elicit potent neutralization against multiple SARS-CoV-2 omicron subvariants and other variants of concern

mRNA vaccines elicit potent neutralization against multiple SARS-CoV-2 omicron subvariants and other variants of concern

Summary: SARS-CoV-2 variants of concern (VOCs) have shown resistance to vaccines targeting the original virus strain. An mRNA vaccine encoding the spike protein of Omicron BA1 (BA1-S-mRNA) was designed, and its neutralizing activity, with or without the original receptor-binding domain (RBD)-mRNA, w...

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Bibliographic Details
Main Authors: Gang Wang, Juan Shi, Abhishek K. Verma, Xiaoqing Guan, Stanley Perlman, Lanying Du
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Molecular biology
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222019630

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