Insecticide resistance modifies mosquito response to DEET and natural repellents
Abstract Background Pyrethroid and organophosphate resistance in the malaria vector Anopheles gambiae has led to the search for not only alternative insecticides, but also repellent chemical compounds. However, little is known about the potential actions of repellents and the cross-resistance risk b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13071-019-3343-9 |
| _version_ | 1831678682448527360 |
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| author | Emilie Deletre Thibaud Martin Claire Duménil Fabrice Chandre |
| author_facet | Emilie Deletre Thibaud Martin Claire Duménil Fabrice Chandre |
| author_sort | Emilie Deletre |
| collection | DOAJ |
| description | Abstract Background Pyrethroid and organophosphate resistance in the malaria vector Anopheles gambiae has led to the search for not only alternative insecticides, but also repellent chemical compounds. However, little is known about the potential actions of repellents and the cross-resistance risk between insecticide and repellent compounds. Methods Here we show the action of permethrin, DEET, geraniol, carvacrol, culminaldehyde and cinnamaldehyde against three A. gambiae strains: ‘Kis’ (Kisumu susceptible strain), ‘KdrKis’ (pyrethroid resistant strain) and ‘AcerKis’ (organophosphate resistant strain), the last two differing from the first by a mutation on the kdr and ace1 genes, respectively. Conclusions Results from the DEET assays show it induced repellency for the resistant KdrKis and AcerKis strains but maintained irritancy for the susceptible strain. More generally, we show resistance genes modify the behavior of An. gambiae, increasing or decreasing the effectiveness of DEET and natural compounds, depending on the mutation. These findings offer a new avenue for research on the target and mechanism of repellent compounds. We discuss these findings in the context of vector control strategies. |
| first_indexed | 2024-12-20T05:04:23Z |
| format | Article |
| id | doaj.art-a9929c96724f4af4a0e1d91e252ab603 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-20T05:04:23Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-a9929c96724f4af4a0e1d91e252ab6032022-12-21T19:52:28ZengBMCParasites & Vectors1756-33052019-03-0112111010.1186/s13071-019-3343-9Insecticide resistance modifies mosquito response to DEET and natural repellentsEmilie Deletre0Thibaud Martin1Claire Duménil2Fabrice Chandre3Cirad - Montpellier University - UPR HortsysCirad - Montpellier University - UPR HortsysCirad - Montpellier University - UPR HortsysUMR MIVEGEC, IRD-CNRS-Montpellier UniversityAbstract Background Pyrethroid and organophosphate resistance in the malaria vector Anopheles gambiae has led to the search for not only alternative insecticides, but also repellent chemical compounds. However, little is known about the potential actions of repellents and the cross-resistance risk between insecticide and repellent compounds. Methods Here we show the action of permethrin, DEET, geraniol, carvacrol, culminaldehyde and cinnamaldehyde against three A. gambiae strains: ‘Kis’ (Kisumu susceptible strain), ‘KdrKis’ (pyrethroid resistant strain) and ‘AcerKis’ (organophosphate resistant strain), the last two differing from the first by a mutation on the kdr and ace1 genes, respectively. Conclusions Results from the DEET assays show it induced repellency for the resistant KdrKis and AcerKis strains but maintained irritancy for the susceptible strain. More generally, we show resistance genes modify the behavior of An. gambiae, increasing or decreasing the effectiveness of DEET and natural compounds, depending on the mutation. These findings offer a new avenue for research on the target and mechanism of repellent compounds. We discuss these findings in the context of vector control strategies.http://link.springer.com/article/10.1186/s13071-019-3343-9Anopheles gambiaePermethrinDeterrentMortalityGeraniolCinnamaldehyde |
| spellingShingle | Emilie Deletre Thibaud Martin Claire Duménil Fabrice Chandre Insecticide resistance modifies mosquito response to DEET and natural repellents Parasites & Vectors Anopheles gambiae Permethrin Deterrent Mortality Geraniol Cinnamaldehyde |
| title | Insecticide resistance modifies mosquito response to DEET and natural repellents |
| title_full | Insecticide resistance modifies mosquito response to DEET and natural repellents |
| title_fullStr | Insecticide resistance modifies mosquito response to DEET and natural repellents |
| title_full_unstemmed | Insecticide resistance modifies mosquito response to DEET and natural repellents |
| title_short | Insecticide resistance modifies mosquito response to DEET and natural repellents |
| title_sort | insecticide resistance modifies mosquito response to deet and natural repellents |
| topic | Anopheles gambiae Permethrin Deterrent Mortality Geraniol Cinnamaldehyde |
| url | http://link.springer.com/article/10.1186/s13071-019-3343-9 |
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