Uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome: preliminary results of an ongoing single-center prospective study
The current study aimed to evaluate whether serum uric acid (SUA) level is associated with the risk of kidney failure in primary glomerulonephritis patients (PGN) with nephrotic syndrome. Methods. During 2019, 38 patients with newly-diagnosed PGN and the nephrotic syndrome were prospectively con...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
State Institution «Institute of Nephrology NAMS of Ukraine"
2020-01-01
|
| Series: | Український Журнал Нефрології та Діалізу |
| Subjects: | |
| Online Access: | https://ukrjnd.com.ua/index.php/journal/article/view/389 |
| _version_ | 1797262195468271616 |
|---|---|
| author | M. Kolesnyk N. Stepanova L. Snisar L. Lebid V. Nepomnyaschii S. Savchenko |
| author_facet | M. Kolesnyk N. Stepanova L. Snisar L. Lebid V. Nepomnyaschii S. Savchenko |
| author_sort | M. Kolesnyk |
| collection | DOAJ |
| description |
The current study aimed to evaluate whether serum uric acid (SUA) level is associated with the risk of kidney failure in primary glomerulonephritis patients (PGN) with nephrotic syndrome.
Methods. During 2019, 38 patients with newly-diagnosed PGN and the nephrotic syndrome were prospectively considered for the study which is a fragment of the ongoing study "To evaluate the effect of oxalates and urates metabolism on the evolution of renal diseases".
In addition to routine clinical and laboratory examination, the concentration of serum (SUA) and urine uric acid was determined. According to the CKD-EPI formula, the glomerular filtration rate (GFR) was calculated. Hyperuricemia was considered to be a uric acid concentration ≥420 μmol / l (7 mg/dl) in men and ≥360 μmol / l (6 mg/dl) in women.
All patients enrolled in the study underwent a lifetime renal biopsy under ultrasound.
Results. There were 26/38 (68.4%) men and 12/38 (31.6%) women. The patients’ age ranged from 18 to 69 years and averaged 37 [28-48] years. The CKD duration at the time of hospitalization and carrying out the kidney biopsy was 11.0 [5,2-37,4] months.
Hyperuricemia was defined in 14/38 (37%) patients. SUA had an inverse correlation with the patients’ GFR (r = -0.44; p = 0.003). Uraturia level was associated with the chronic changes’ gradе on the kidney biopsy specimens (r = 0.66; p ˂ 0.00013).
A multivariate logistic analysis (adjustment for albumin, serum creatinine, total blood protein, daily proteinuria, patient age, and hypertension) SUA had an effect on the GFR level (OR 19.2 (95% CI 1.8; 209.5), χ2 = 8.4; p = 0.003).
Conclusions. Hyperuricemia was observed in 37% of PGN patients with nephrotic syndrome and was an independent risk factor for CKD progression. Recruitment of patients continues to complete the statistical analysis and confirm our hypothesis. Patient recruitment is still ongoing to finalize the statistical analyses and to confirm our hypothesis.
|
| first_indexed | 2024-04-24T23:53:15Z |
| format | Article |
| id | doaj.art-a994268e124349f8b422aa7fc79d9c2e |
| institution | Directory Open Access Journal |
| issn | 2304-0238 2616-7352 |
| language | English |
| last_indexed | 2024-04-24T23:53:15Z |
| publishDate | 2020-01-01 |
| publisher | State Institution «Institute of Nephrology NAMS of Ukraine" |
| record_format | Article |
| series | Український Журнал Нефрології та Діалізу |
| spelling | doaj.art-a994268e124349f8b422aa7fc79d9c2e2024-03-14T16:58:11ZengState Institution «Institute of Nephrology NAMS of Ukraine"Український Журнал Нефрології та Діалізу2304-02382616-73522020-01-011(65)10.31450/ukrjnd.1(65).2020.05Uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome: preliminary results of an ongoing single-center prospective studyM. Kolesnyk0N. Stepanova1L. Snisar2L. Lebid3V. Nepomnyaschii4S. Savchenko5SI «Institute of Nephrology of the National Academy of Medical Sciences of Ukraine»SI «Institute of Nephrology of the National Academy of Medical Sciences of Ukraine»SI «Institute of Nephrology of the National Academy of Medical Sciences of Ukraine»SI «Institute of Nephrology of the National Academy of Medical Sciences of Ukraine»SI «Institute of Nephrology of the National Academy of Medical Sciences of Ukraine»SI «Institute of Nephrology of the National Academy of Medical Sciences of Ukraine» The current study aimed to evaluate whether serum uric acid (SUA) level is associated with the risk of kidney failure in primary glomerulonephritis patients (PGN) with nephrotic syndrome. Methods. During 2019, 38 patients with newly-diagnosed PGN and the nephrotic syndrome were prospectively considered for the study which is a fragment of the ongoing study "To evaluate the effect of oxalates and urates metabolism on the evolution of renal diseases". In addition to routine clinical and laboratory examination, the concentration of serum (SUA) and urine uric acid was determined. According to the CKD-EPI formula, the glomerular filtration rate (GFR) was calculated. Hyperuricemia was considered to be a uric acid concentration ≥420 μmol / l (7 mg/dl) in men and ≥360 μmol / l (6 mg/dl) in women. All patients enrolled in the study underwent a lifetime renal biopsy under ultrasound. Results. There were 26/38 (68.4%) men and 12/38 (31.6%) women. The patients’ age ranged from 18 to 69 years and averaged 37 [28-48] years. The CKD duration at the time of hospitalization and carrying out the kidney biopsy was 11.0 [5,2-37,4] months. Hyperuricemia was defined in 14/38 (37%) patients. SUA had an inverse correlation with the patients’ GFR (r = -0.44; p = 0.003). Uraturia level was associated with the chronic changes’ gradе on the kidney biopsy specimens (r = 0.66; p ˂ 0.00013). A multivariate logistic analysis (adjustment for albumin, serum creatinine, total blood protein, daily proteinuria, patient age, and hypertension) SUA had an effect on the GFR level (OR 19.2 (95% CI 1.8; 209.5), χ2 = 8.4; p = 0.003). Conclusions. Hyperuricemia was observed in 37% of PGN patients with nephrotic syndrome and was an independent risk factor for CKD progression. Recruitment of patients continues to complete the statistical analysis and confirm our hypothesis. Patient recruitment is still ongoing to finalize the statistical analyses and to confirm our hypothesis. https://ukrjnd.com.ua/index.php/journal/article/view/389glomerulonephritis, nephrotic syndrome, serum uric acid, glomerular filtration rate, progression. |
| spellingShingle | M. Kolesnyk N. Stepanova L. Snisar L. Lebid V. Nepomnyaschii S. Savchenko Uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome: preliminary results of an ongoing single-center prospective study Український Журнал Нефрології та Діалізу glomerulonephritis, nephrotic syndrome, serum uric acid, glomerular filtration rate, progression. |
| title | Uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome: preliminary results of an ongoing single-center prospective study |
| title_full | Uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome: preliminary results of an ongoing single-center prospective study |
| title_fullStr | Uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome: preliminary results of an ongoing single-center prospective study |
| title_full_unstemmed | Uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome: preliminary results of an ongoing single-center prospective study |
| title_short | Uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome: preliminary results of an ongoing single-center prospective study |
| title_sort | uric acid and the risk of kidney failure in primary glomerulonephritis patients with nephrotic syndrome preliminary results of an ongoing single center prospective study |
| topic | glomerulonephritis, nephrotic syndrome, serum uric acid, glomerular filtration rate, progression. |
| url | https://ukrjnd.com.ua/index.php/journal/article/view/389 |
| work_keys_str_mv | AT mkolesnyk uricacidandtheriskofkidneyfailureinprimaryglomerulonephritispatientswithnephroticsyndromepreliminaryresultsofanongoingsinglecenterprospectivestudy AT nstepanova uricacidandtheriskofkidneyfailureinprimaryglomerulonephritispatientswithnephroticsyndromepreliminaryresultsofanongoingsinglecenterprospectivestudy AT lsnisar uricacidandtheriskofkidneyfailureinprimaryglomerulonephritispatientswithnephroticsyndromepreliminaryresultsofanongoingsinglecenterprospectivestudy AT llebid uricacidandtheriskofkidneyfailureinprimaryglomerulonephritispatientswithnephroticsyndromepreliminaryresultsofanongoingsinglecenterprospectivestudy AT vnepomnyaschii uricacidandtheriskofkidneyfailureinprimaryglomerulonephritispatientswithnephroticsyndromepreliminaryresultsofanongoingsinglecenterprospectivestudy AT ssavchenko uricacidandtheriskofkidneyfailureinprimaryglomerulonephritispatientswithnephroticsyndromepreliminaryresultsofanongoingsinglecenterprospectivestudy |