Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats
Abstract The high consumption of sugars is linked to the intermediate hyperglycemia and impaired glucose tolerance associated with obesity, inducing the prediabetes. However, the consequences of excessive invert sugar intake on glucose metabolism and genomic stability were poorly studied. The aim of...
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Academia Brasileira de Ciências
2020-07-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300906&tlng=en |
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| author | PATRÍCIA MOLZ WALTER A. MOLZ DANIELI R. DALLEMOLE LUCIANA F.S. SANTOS MIRIAN SALVADOR DENNIS B. CRUZ DANIEL PRÁ SILVIA I.R. FRANKE |
| author_facet | PATRÍCIA MOLZ WALTER A. MOLZ DANIELI R. DALLEMOLE LUCIANA F.S. SANTOS MIRIAN SALVADOR DENNIS B. CRUZ DANIEL PRÁ SILVIA I.R. FRANKE |
| author_sort | PATRÍCIA MOLZ |
| collection | DOAJ |
| description | Abstract The high consumption of sugars is linked to the intermediate hyperglycemia and impaired glucose tolerance associated with obesity, inducing the prediabetes. However, the consequences of excessive invert sugar intake on glucose metabolism and genomic stability were poorly studied. The aim of this study was to evaluate the effects of invert sugar overload (32%) in rats, analyzing changes in obesity, glucose tolerance, pancreatic/hepatic histology and primary and permanent DNA damage. After 17 weeks, the rats became obese and had an excessive abdominal fat, as well as presented impaired glucose tolerance, caused by higher sugar caloric intake. Primary DNA damage, evaluated by the comet assay, was increased in the blood, however not in the pancreas. No protein carbonylation was seen in serum. Moreover, no increase in permanent DNA damage was seen in the bone marrow, evaluated using the micronucleus test. Some rats presented liver steatosis and that the pancreatic islets were enlarged, but not significantly. In this study, invert sugar altered the glucose metabolism and induced primary DNA damage in blood, but did not cause significant damage to the pancreas or liver, and neither changes in the levels of oxidative stress or permanent DNA damage. |
| first_indexed | 2024-12-17T20:13:35Z |
| format | Article |
| id | doaj.art-a996cf482a904fb081eb3f3233ab691f |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-17T20:13:35Z |
| publishDate | 2020-07-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-a996cf482a904fb081eb3f3233ab691f2022-12-21T21:34:10ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902020-07-0192210.1590/0001-3765202020191423Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in ratsPATRÍCIA MOLZhttps://orcid.org/0000-0001-8940-7023WALTER A. MOLZhttps://orcid.org/0000-0001-5992-6498DANIELI R. DALLEMOLEhttps://orcid.org/0000-0002-3860-7487LUCIANA F.S. SANTOShttps://orcid.org/0000-0002-9887-1765MIRIAN SALVADORhttps://orcid.org/0000-0001-9404-0262DENNIS B. CRUZhttps://orcid.org/0000-0002-5247-1571DANIEL PRÁhttps://orcid.org/0000-0003-2818-0173SILVIA I.R. FRANKEhttps://orcid.org/0000-0002-1935-3231Abstract The high consumption of sugars is linked to the intermediate hyperglycemia and impaired glucose tolerance associated with obesity, inducing the prediabetes. However, the consequences of excessive invert sugar intake on glucose metabolism and genomic stability were poorly studied. The aim of this study was to evaluate the effects of invert sugar overload (32%) in rats, analyzing changes in obesity, glucose tolerance, pancreatic/hepatic histology and primary and permanent DNA damage. After 17 weeks, the rats became obese and had an excessive abdominal fat, as well as presented impaired glucose tolerance, caused by higher sugar caloric intake. Primary DNA damage, evaluated by the comet assay, was increased in the blood, however not in the pancreas. No protein carbonylation was seen in serum. Moreover, no increase in permanent DNA damage was seen in the bone marrow, evaluated using the micronucleus test. Some rats presented liver steatosis and that the pancreatic islets were enlarged, but not significantly. In this study, invert sugar altered the glucose metabolism and induced primary DNA damage in blood, but did not cause significant damage to the pancreas or liver, and neither changes in the levels of oxidative stress or permanent DNA damage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300906&tlng=eninvert sugarglucose metabolismobesityprediabetesDNA damagehistopathology |
| spellingShingle | PATRÍCIA MOLZ WALTER A. MOLZ DANIELI R. DALLEMOLE LUCIANA F.S. SANTOS MIRIAN SALVADOR DENNIS B. CRUZ DANIEL PRÁ SILVIA I.R. FRANKE Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats Anais da Academia Brasileira de Ciências invert sugar glucose metabolism obesity prediabetes DNA damage histopathology |
| title | Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats |
| title_full | Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats |
| title_fullStr | Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats |
| title_full_unstemmed | Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats |
| title_short | Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats |
| title_sort | invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent dna damage in rats |
| topic | invert sugar glucose metabolism obesity prediabetes DNA damage histopathology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300906&tlng=en |
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