Development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy: a prospective cohort study
BackgroundThe casual relationship between the role of cholecystectomy and functional gastrointestinal disorders (FGIDs) are a controversial clinical challenge. This study aimed to investigate: (1) the overlap of FGIDs before cholecystectomy and its long-term outcome after surgery in patients with sy...
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| Format: | Article |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1248465/full |
| _version_ | 1827798910116036608 |
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| author | Ji Young Chang Hye-Kyung Jung Chang Mo Moon Seong-Eun Kim Ki-Nam Shim Sung-Ae Jung Seog Ki Min |
| author_facet | Ji Young Chang Hye-Kyung Jung Chang Mo Moon Seong-Eun Kim Ki-Nam Shim Sung-Ae Jung Seog Ki Min |
| author_sort | Ji Young Chang |
| collection | DOAJ |
| description | BackgroundThe casual relationship between the role of cholecystectomy and functional gastrointestinal disorders (FGIDs) are a controversial clinical challenge. This study aimed to investigate: (1) the overlap of FGIDs before cholecystectomy and its long-term outcome after surgery in patients with symptomatic cholelithiasis, and (2) the incidence of new-onset FGIDs after cholecystectomy.MethodsPatients with symptomatic gallstone disease who underwent elective, laparoscopic cholecystectomy were prospectively enrolled. Healthy populations who underwent medical check-ups were selected as age- and sex-matched controls. Questionnaires regarding sociodemographic characteristics, gastrointestinal symptoms and a somatization symptom checklist (SSC) were completed at baseline and 12 months thereafter.ResultsThe prevalence of all FGID symptoms before cholecystectomy were significantly higher in the group of patients with symptomatic cholecystolithiasis compared to the control group. In cholecystectomy group, the preoperative FGID symptoms improved after surgery, except for chronic diarrhea. Compared to the controls, the new-onset FGIDs, including functional dyspepsia (14.8% vs. 6.9%; p = 0.040), functional diarrhea (6.6% vs. 0.2%; p < 0.001), and chronic abdominal pain (11.9% vs. 4.4%; p = 0.024), were more common at 1 year after cholecystectomy. Somatization was independent predictors of new-onset dyspepsia and abdominal pain, while newly occurring diarrhea was not realted to somatization.ConclusionOverlap of FGIDs was common in patients with symptomatic cholelithiasis before surgery and at follow-up 1 year after cholecystectomy. Furthermore, new-onset FGIDs could be occurred after cholecystectomy. Therefore, a delicate diagnostic approaches and appropriate treatments about co-existent FGIDs should be given in patients with cholelithiasis before and after cholecystectomy. |
| first_indexed | 2024-03-11T19:42:43Z |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-11T19:42:43Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-a996e1c9b7cf4fc899768895352688c92023-10-06T07:13:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-10-011010.3389/fmed.2023.12484651248465Development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy: a prospective cohort studyJi Young Chang0Hye-Kyung Jung1Chang Mo Moon2Seong-Eun Kim3Ki-Nam Shim4Sung-Ae Jung5Seog Ki Min6Department of Health Promotion Medicine, Ewha Womans University Seoul Hostpial, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaDepartment of Surgery, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaBackgroundThe casual relationship between the role of cholecystectomy and functional gastrointestinal disorders (FGIDs) are a controversial clinical challenge. This study aimed to investigate: (1) the overlap of FGIDs before cholecystectomy and its long-term outcome after surgery in patients with symptomatic cholelithiasis, and (2) the incidence of new-onset FGIDs after cholecystectomy.MethodsPatients with symptomatic gallstone disease who underwent elective, laparoscopic cholecystectomy were prospectively enrolled. Healthy populations who underwent medical check-ups were selected as age- and sex-matched controls. Questionnaires regarding sociodemographic characteristics, gastrointestinal symptoms and a somatization symptom checklist (SSC) were completed at baseline and 12 months thereafter.ResultsThe prevalence of all FGID symptoms before cholecystectomy were significantly higher in the group of patients with symptomatic cholecystolithiasis compared to the control group. In cholecystectomy group, the preoperative FGID symptoms improved after surgery, except for chronic diarrhea. Compared to the controls, the new-onset FGIDs, including functional dyspepsia (14.8% vs. 6.9%; p = 0.040), functional diarrhea (6.6% vs. 0.2%; p < 0.001), and chronic abdominal pain (11.9% vs. 4.4%; p = 0.024), were more common at 1 year after cholecystectomy. Somatization was independent predictors of new-onset dyspepsia and abdominal pain, while newly occurring diarrhea was not realted to somatization.ConclusionOverlap of FGIDs was common in patients with symptomatic cholelithiasis before surgery and at follow-up 1 year after cholecystectomy. Furthermore, new-onset FGIDs could be occurred after cholecystectomy. Therefore, a delicate diagnostic approaches and appropriate treatments about co-existent FGIDs should be given in patients with cholelithiasis before and after cholecystectomy.https://www.frontiersin.org/articles/10.3389/fmed.2023.1248465/fulldiarrheadyspepsiachronic abdominal paincholecystectomypost-cholecystectomy syndrome |
| spellingShingle | Ji Young Chang Hye-Kyung Jung Chang Mo Moon Seong-Eun Kim Ki-Nam Shim Sung-Ae Jung Seog Ki Min Development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy: a prospective cohort study Frontiers in Medicine diarrhea dyspepsia chronic abdominal pain cholecystectomy post-cholecystectomy syndrome |
| title | Development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy: a prospective cohort study |
| title_full | Development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy: a prospective cohort study |
| title_fullStr | Development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy: a prospective cohort study |
| title_full_unstemmed | Development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy: a prospective cohort study |
| title_short | Development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy: a prospective cohort study |
| title_sort | development of functional gastrointestinal disorder symptoms following laparoscopic cholecystectomy a prospective cohort study |
| topic | diarrhea dyspepsia chronic abdominal pain cholecystectomy post-cholecystectomy syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1248465/full |
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