Molecular dissection of an immunodominant epitope in Kv1.2-exclusive autoimmunity

Molecular dissection of an immunodominant epitope in Kv1.2-exclusive autoimmunity

IntroductionSubgroups of autoantibodies directed against voltage-gated potassium channel (Kv) complex components have been associated with immunotherapy-responsive clinical syndromes. The high prevalence and the role of autoantibodies directly binding Kv remain, however, controversial. Our objective...

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Main Authors: Ivan Talucci, Friederike A. Arlt, Kai O. Kreissner, Mahoor Nasouti, Anna-Lena Wiessler, Ramona Miske, Swantje Mindorf, Inga Dettmann, Mehrnaz Moniri, Markus Bayer, Peter Broegger Christensen, Ilya Ayzenberg, Andrea Kraft, Matthias Endres, Lars Komorowski, Carmen Villmann, Kathrin Doppler, Harald Prüss, Hans M. Maric
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
autoantibodies
Kv channel
KCNA2
autoimmune encephalitis
epitope mapping
immunodominant antigen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1329013/full

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