The effect of OCT-2 inhibitor Daclatasvir on Metformin pharmacokinetics and pharmacodynamics at two dose levels: A Bayesian approach using Markov-Chain Monte Carlo simulations

The effect of OCT-2 inhibitor Daclatasvir on Metformin pharmacokinetics and pharmacodynamics at two dose levels: A Bayesian approach using Markov-Chain Monte Carlo simulations

Renal Organic Cation Transporter 2 (OCT2) plays a major role in metformin elimination. Daclatasvir, a Direct-Acting Antiviral (DAA), is an OCT2 inhibitor. Our study aimed to assess the potential interaction of daclatasvir with metformin pharmacokinetics and pharmacodynamics at two metformin doses. T...

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Bibliographic Details
Main Authors: Mohamed Raslan, Lamia Elwakeel, Sara Shahin
Format: Article
Language:English
Published: Ain Shams University 2022-12-01
Series:Archives of Pharmaceutical Sciences Ain Shams University
Subjects:
metformin
daclatasvir
oct2
pharmacokinetics
pharmacodynamics
mcmc
Online Access:https://aps.journals.ekb.eg/article_281273.html

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