Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning
Abstract Background Radioisotope scanning is important to diagnose subacute thyroiditis (SAT), but it’s not always available. So we aim to establish a diagnostic scale for SAT without radioisotope scanning. Methods The suspected SAT patients hospitalized in Yuebei people’s Hospital from January 2012...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12902-020-00554-z |
| _version_ | 1818420239446048768 |
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| author | Zhouyi Xiong Chunying Luo Li Wang Bin Xiong Jianneng Wu |
| author_facet | Zhouyi Xiong Chunying Luo Li Wang Bin Xiong Jianneng Wu |
| author_sort | Zhouyi Xiong |
| collection | DOAJ |
| description | Abstract Background Radioisotope scanning is important to diagnose subacute thyroiditis (SAT), but it’s not always available. So we aim to establish a diagnostic scale for SAT without radioisotope scanning. Methods The suspected SAT patients hospitalized in Yuebei people’s Hospital from January 2012 to December 2016 were selected and divided into study group and control group according to whether they were diagnosed as SAT. The clinical indexes of two groups were collected and the diagnostic scale of SAT was established by using binary logistic regression analysis. The effectiveness of the scale was evaluated by ROC curve. Results Of 309 patients, 58.25% of patients were confirmed with SAT and the remaining 41.75% of patients were not diagnosed with SAT. After univariate analysis, variables which were considered statistically different(P < 0. 05) between the two groups were selected as independent variables and the diagnosis of SAT was taken as dependent variable in the binary logistic regression model. The logistic regression model consisted of 4 variables, each was thyroid tenderness, firm on palpation, increased ESR and elevated thyroid hormone level. The P value of Omnibus tests was≤0. 001 and the Nagelkerke R Square was 0. 915. The diagnostic scoring scale was established with these four variables according to their regression coefficient. The area under the ROC curve for this diagnostic scale was 0. 991(95% confidence interval, 0. 982–0.999). The highest Youden index was 0. 912, the corresponding cut-off point was 7. Internally validation shows a sensitivity of 92. 78% and a specificity of 98.45% of our scale. Conclusions We established and validated a diagnostic scale for SAT without the need for radioisotope scanning for the first time. It has good application in institutions that do not have radioisotope machines or among pregnant and lactating women. |
| first_indexed | 2024-12-14T12:51:18Z |
| format | Article |
| id | doaj.art-a99cae8fdf204379bb954ce697430c21 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-14T12:51:18Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-a99cae8fdf204379bb954ce697430c212022-12-21T23:00:40ZengBMCBMC Endocrine Disorders1472-68232020-05-012011610.1186/s12902-020-00554-zEstablishing a diagnostic scale of subacute thyroiditis without radioisotope scanningZhouyi Xiong0Chunying Luo1Li Wang2Bin Xiong3Jianneng Wu4Department of Endocrinology, Yuebei People’s HospitalDepartment of Endocrinology, Yuebei People’s HospitalDepartment of Endocrinology, Yuebei People’s HospitalDepartment of Endocrinology, Yuebei People’s HospitalDepartment of Endocrinology, Yuebei People’s HospitalAbstract Background Radioisotope scanning is important to diagnose subacute thyroiditis (SAT), but it’s not always available. So we aim to establish a diagnostic scale for SAT without radioisotope scanning. Methods The suspected SAT patients hospitalized in Yuebei people’s Hospital from January 2012 to December 2016 were selected and divided into study group and control group according to whether they were diagnosed as SAT. The clinical indexes of two groups were collected and the diagnostic scale of SAT was established by using binary logistic regression analysis. The effectiveness of the scale was evaluated by ROC curve. Results Of 309 patients, 58.25% of patients were confirmed with SAT and the remaining 41.75% of patients were not diagnosed with SAT. After univariate analysis, variables which were considered statistically different(P < 0. 05) between the two groups were selected as independent variables and the diagnosis of SAT was taken as dependent variable in the binary logistic regression model. The logistic regression model consisted of 4 variables, each was thyroid tenderness, firm on palpation, increased ESR and elevated thyroid hormone level. The P value of Omnibus tests was≤0. 001 and the Nagelkerke R Square was 0. 915. The diagnostic scoring scale was established with these four variables according to their regression coefficient. The area under the ROC curve for this diagnostic scale was 0. 991(95% confidence interval, 0. 982–0.999). The highest Youden index was 0. 912, the corresponding cut-off point was 7. Internally validation shows a sensitivity of 92. 78% and a specificity of 98.45% of our scale. Conclusions We established and validated a diagnostic scale for SAT without the need for radioisotope scanning for the first time. It has good application in institutions that do not have radioisotope machines or among pregnant and lactating women.http://link.springer.com/article/10.1186/s12902-020-00554-zSubacute thyroiditisRadioisotope scanningDiagnostic scaleLogistic regression analysis |
| spellingShingle | Zhouyi Xiong Chunying Luo Li Wang Bin Xiong Jianneng Wu Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning BMC Endocrine Disorders Subacute thyroiditis Radioisotope scanning Diagnostic scale Logistic regression analysis |
| title | Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning |
| title_full | Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning |
| title_fullStr | Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning |
| title_full_unstemmed | Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning |
| title_short | Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning |
| title_sort | establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning |
| topic | Subacute thyroiditis Radioisotope scanning Diagnostic scale Logistic regression analysis |
| url | http://link.springer.com/article/10.1186/s12902-020-00554-z |
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