Trex2 responds to damaged replication forks in diverse ways

Three prime Repair Exonuclease 2 (Trex2) alters replication fork (RF) stability and mutation levels in cells defective for homologous recombination (HR). Trex2 has multiple functions that can either cause or supress RF instability in cells with different HR-defects. Why does Trex2 have such diverse...

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Bibliographic Details
Main Author: Paul Hasty
Format: Article
Language:English
Published: Taylor & Francis Group 2021-03-01
Series:Molecular & Cellular Oncology
Online Access:http://dx.doi.org/10.1080/23723556.2021.1881394