Mast cells in invasive ductal breast carcinoma
<ul> <li><strong>BACKGROUND</strong>: Inflammatory cells in the tumor stroma have gained increasing interests recently. We aimed to study the prognostic impact of the presence of stromal mast cells in invasive breast carcinomas.</li&...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2008-10-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://journals.mui.ac.ir/jrms/article/view/1568 |
| Summary: | <ul> <li><strong>BACKGROUND</strong>: Inflammatory cells in the tumor stroma have gained increasing interests recently. We aimed to study the prognostic impact of the presence of stromal mast cells in invasive breast carcinomas.</li> <li><strong>METHODS</strong>: Tissue sections of 108 cases with invasive breast cancers were prepared and stained with Giemsa. The presence of stromal mast cells were evaluated and its correlation with tumor&rsquo;s grade, tumor size, positivity for estrogen and progesterone receptors (ER and PR, respectively), HER2/neu positivity and lymph node metastasis was analysed.</li> <li><strong>RESULTS</strong>: The median age was 52.3 years (range 28-85 years). Grading was done according to the Nottingham Modification of the Bloom-Richardson system. Fifty-four (50%) women had grade 1, 16 (14.8%) had grade 2 and 38 (35.2%) had grade 3 tumor. The presence of stromal mast cells correlated significantly to low grade tumors (p = 0.004) and ER Positivity (p = 0.04). There was no correlation between the presence of stromal mast cells and the PR positivity, HER2/neu positivity, tumor size and lymph node metastasis (p > 0.05).</li> <li><strong>CONCLUSIONS</strong>: Our results indicated that the presence of mast cells in breast cancer is correlated with a much lower grade of this tumor. Also in our study, there was a positive correlation between ER receptor positivity and the presence of mast cells in the stroma of breast cancer.</li> <li><strong>KEY WORDS</strong>: Invasive ductal carcinoma, mast cell, prognosis.</li> </ul> |
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| ISSN: | 1735-1995 1735-7136 |