Mast cells in invasive ductal breast carcinoma
<ul> <li><strong>BACKGROUND</strong>: Inflammatory cells in the tumor stroma have gained increasing interests recently. We aimed to study the prognostic impact of the presence of stromal mast cells in invasive breast carcinomas.</li&...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2008-10-01
|
Series: | Journal of Research in Medical Sciences |
Subjects: | |
Online Access: | http://journals.mui.ac.ir/jrms/article/view/1568 |
_version_ | 1811321798631882752 |
---|---|
author | Mitra Heidarpour Mohammad Ali Rajabi Parvin Rajabi Hossein SafarAli Farkhani |
author_facet | Mitra Heidarpour Mohammad Ali Rajabi Parvin Rajabi Hossein SafarAli Farkhani |
author_sort | Mitra Heidarpour |
collection | DOAJ |
description | <ul> <li><strong>BACKGROUND</strong>: Inflammatory cells in the tumor stroma have gained increasing interests recently. We aimed to study the prognostic impact of the presence of stromal mast cells in invasive breast carcinomas.</li> <li><strong>METHODS</strong>: Tissue sections of 108 cases with invasive breast cancers were prepared and stained with Giemsa. The presence of stromal mast cells were evaluated and its correlation with tumor&rsquo;s grade, tumor size, positivity for estrogen and progesterone receptors (ER and PR, respectively), HER2/neu positivity and lymph node metastasis was analysed.</li> <li><strong>RESULTS</strong>: The median age was 52.3 years (range 28-85 years). Grading was done according to the Nottingham Modification of the Bloom-Richardson system. Fifty-four (50%) women had grade 1, 16 (14.8%) had grade 2 and 38 (35.2%) had grade 3 tumor. The presence of stromal mast cells correlated significantly to low grade tumors (p = 0.004) and ER Positivity (p = 0.04). There was no correlation between the presence of stromal mast cells and the PR positivity, HER2/neu positivity, tumor size and lymph node metastasis (p > 0.05).</li> <li><strong>CONCLUSIONS</strong>: Our results indicated that the presence of mast cells in breast cancer is correlated with a much lower grade of this tumor. Also in our study, there was a positive correlation between ER receptor positivity and the presence of mast cells in the stroma of breast cancer.</li> <li><strong>KEY WORDS</strong>: Invasive ductal carcinoma, mast cell, prognosis.</li> </ul> |
first_indexed | 2024-04-13T13:24:07Z |
format | Article |
id | doaj.art-a99f1cace2984865b42b6915eb0093ef |
institution | Directory Open Access Journal |
issn | 1735-1995 1735-7136 |
language | English |
last_indexed | 2024-04-13T13:24:07Z |
publishDate | 2008-10-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Journal of Research in Medical Sciences |
spelling | doaj.art-a99f1cace2984865b42b6915eb0093ef2022-12-22T02:45:13ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362008-10-01135255259Mast cells in invasive ductal breast carcinomaMitra HeidarpourMohammad Ali RajabiParvin RajabiHossein SafarAli Farkhani<ul> <li><strong>BACKGROUND</strong>: Inflammatory cells in the tumor stroma have gained increasing interests recently. We aimed to study the prognostic impact of the presence of stromal mast cells in invasive breast carcinomas.</li> <li><strong>METHODS</strong>: Tissue sections of 108 cases with invasive breast cancers were prepared and stained with Giemsa. The presence of stromal mast cells were evaluated and its correlation with tumor&rsquo;s grade, tumor size, positivity for estrogen and progesterone receptors (ER and PR, respectively), HER2/neu positivity and lymph node metastasis was analysed.</li> <li><strong>RESULTS</strong>: The median age was 52.3 years (range 28-85 years). Grading was done according to the Nottingham Modification of the Bloom-Richardson system. Fifty-four (50%) women had grade 1, 16 (14.8%) had grade 2 and 38 (35.2%) had grade 3 tumor. The presence of stromal mast cells correlated significantly to low grade tumors (p = 0.004) and ER Positivity (p = 0.04). There was no correlation between the presence of stromal mast cells and the PR positivity, HER2/neu positivity, tumor size and lymph node metastasis (p > 0.05).</li> <li><strong>CONCLUSIONS</strong>: Our results indicated that the presence of mast cells in breast cancer is correlated with a much lower grade of this tumor. Also in our study, there was a positive correlation between ER receptor positivity and the presence of mast cells in the stroma of breast cancer.</li> <li><strong>KEY WORDS</strong>: Invasive ductal carcinoma, mast cell, prognosis.</li> </ul>http://journals.mui.ac.ir/jrms/article/view/1568Invasive ductal carcinoma, mast cell, prognosis. |
spellingShingle | Mitra Heidarpour Mohammad Ali Rajabi Parvin Rajabi Hossein SafarAli Farkhani Mast cells in invasive ductal breast carcinoma Journal of Research in Medical Sciences Invasive ductal carcinoma, mast cell, prognosis. |
title | Mast cells in invasive ductal breast carcinoma |
title_full | Mast cells in invasive ductal breast carcinoma |
title_fullStr | Mast cells in invasive ductal breast carcinoma |
title_full_unstemmed | Mast cells in invasive ductal breast carcinoma |
title_short | Mast cells in invasive ductal breast carcinoma |
title_sort | mast cells in invasive ductal breast carcinoma |
topic | Invasive ductal carcinoma, mast cell, prognosis. |
url | http://journals.mui.ac.ir/jrms/article/view/1568 |
work_keys_str_mv | AT mitraheidarpour mastcellsininvasiveductalbreastcarcinoma AT mohammadalirajabi mastcellsininvasiveductalbreastcarcinoma AT parvinrajabi mastcellsininvasiveductalbreastcarcinoma AT hosseinsafaralifarkhani mastcellsininvasiveductalbreastcarcinoma |