Mast cells in invasive ductal breast carcinoma

<ul> <li><strong>BACKGROUND</strong>: Inflammatory cells in the tumor stroma have gained increasing interests recently. We aimed to study the prognostic impact of the presence of stromal mast cells in invasive breast carcinomas.</li&...

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Main Authors: Mitra Heidarpour, Mohammad Ali Rajabi, Parvin Rajabi, Hossein SafarAli Farkhani
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2008-10-01
Series:Journal of Research in Medical Sciences
Subjects:
Online Access:http://journals.mui.ac.ir/jrms/article/view/1568
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author Mitra Heidarpour
Mohammad Ali Rajabi
Parvin Rajabi
Hossein SafarAli Farkhani
author_facet Mitra Heidarpour
Mohammad Ali Rajabi
Parvin Rajabi
Hossein SafarAli Farkhani
author_sort Mitra Heidarpour
collection DOAJ
description <ul> <li><strong>BACKGROUND</strong>: Inflammatory cells in the tumor stroma have gained increasing interests recently. We aimed to study the prognostic impact of the presence of stromal mast cells in invasive breast carcinomas.</li> <li><strong>METHODS</strong>: Tissue sections of 108 cases with invasive breast cancers were prepared and stained with Giemsa. The presence of stromal mast cells were evaluated and its correlation with tumor’s grade, tumor size, positivity for estrogen and progesterone receptors (ER and PR, respectively), HER2/neu positivity and lymph node metastasis was analysed.</li> <li><strong>RESULTS</strong>: The median age was 52.3 years (range 28-85 years). Grading was done according to the Nottingham Modification of the Bloom-Richardson system. Fifty-four (50%) women had grade 1, 16 (14.8%) had grade 2 and 38 (35.2%) had grade 3 tumor. The presence of stromal mast cells correlated significantly to low grade tumors (p = 0.004) and ER Positivity (p = 0.04). There was no correlation between the presence of stromal mast cells and the PR positivity, HER2/neu positivity, tumor size and lymph node metastasis (p > 0.05).</li> <li><strong>CONCLUSIONS</strong>: Our results indicated that the presence of mast cells in breast cancer is correlated with a much lower grade of this tumor. Also in our study, there was a positive correlation between ER receptor positivity and the presence of mast cells in the stroma of breast cancer.</li> <li><strong>KEY WORDS</strong>: Invasive ductal carcinoma, mast cell, prognosis.</li> </ul>
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spelling doaj.art-a99f1cace2984865b42b6915eb0093ef2022-12-22T02:45:13ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362008-10-01135255259Mast cells in invasive ductal breast carcinomaMitra HeidarpourMohammad Ali RajabiParvin RajabiHossein SafarAli Farkhani<ul> <li><strong>BACKGROUND</strong>: Inflammatory cells in the tumor stroma have gained increasing interests recently. We aimed to study the prognostic impact of the presence of stromal mast cells in invasive breast carcinomas.</li> <li><strong>METHODS</strong>: Tissue sections of 108 cases with invasive breast cancers were prepared and stained with Giemsa. The presence of stromal mast cells were evaluated and its correlation with tumor’s grade, tumor size, positivity for estrogen and progesterone receptors (ER and PR, respectively), HER2/neu positivity and lymph node metastasis was analysed.</li> <li><strong>RESULTS</strong>: The median age was 52.3 years (range 28-85 years). Grading was done according to the Nottingham Modification of the Bloom-Richardson system. Fifty-four (50%) women had grade 1, 16 (14.8%) had grade 2 and 38 (35.2%) had grade 3 tumor. The presence of stromal mast cells correlated significantly to low grade tumors (p = 0.004) and ER Positivity (p = 0.04). There was no correlation between the presence of stromal mast cells and the PR positivity, HER2/neu positivity, tumor size and lymph node metastasis (p > 0.05).</li> <li><strong>CONCLUSIONS</strong>: Our results indicated that the presence of mast cells in breast cancer is correlated with a much lower grade of this tumor. Also in our study, there was a positive correlation between ER receptor positivity and the presence of mast cells in the stroma of breast cancer.</li> <li><strong>KEY WORDS</strong>: Invasive ductal carcinoma, mast cell, prognosis.</li> </ul>http://journals.mui.ac.ir/jrms/article/view/1568Invasive ductal carcinoma, mast cell, prognosis.
spellingShingle Mitra Heidarpour
Mohammad Ali Rajabi
Parvin Rajabi
Hossein SafarAli Farkhani
Mast cells in invasive ductal breast carcinoma
Journal of Research in Medical Sciences
Invasive ductal carcinoma, mast cell, prognosis.
title Mast cells in invasive ductal breast carcinoma
title_full Mast cells in invasive ductal breast carcinoma
title_fullStr Mast cells in invasive ductal breast carcinoma
title_full_unstemmed Mast cells in invasive ductal breast carcinoma
title_short Mast cells in invasive ductal breast carcinoma
title_sort mast cells in invasive ductal breast carcinoma
topic Invasive ductal carcinoma, mast cell, prognosis.
url http://journals.mui.ac.ir/jrms/article/view/1568
work_keys_str_mv AT mitraheidarpour mastcellsininvasiveductalbreastcarcinoma
AT mohammadalirajabi mastcellsininvasiveductalbreastcarcinoma
AT parvinrajabi mastcellsininvasiveductalbreastcarcinoma
AT hosseinsafaralifarkhani mastcellsininvasiveductalbreastcarcinoma