An Overview of Cancer in the First 315,000 All of Us Participants.
<h4>Introduction</h4>The NIH All of Us Research Program will have the scale and scope to enable research for a wide range of diseases, including cancer. The program's focus on diversity and inclusion promises a better understanding of the unequal burden of cancer. Preliminary cancer...
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0272522 |
| _version_ | 1797848124096512000 |
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| author | Briseis Aschebrook-Kilfoy Paul Zakin Andrew Craver Sameep Shah Muhammad G Kibriya Elizabeth Stepniak Andrea Ramirez Cheryl Clark Elizabeth Cohn Lucila Ohno-Machado Mine Cicek Eric Boerwinkle Sheri D Schully Stephen Mockrin Kelly Gebo Kelsey Mayo Francis Ratsimbazafy Alan Sanders Raj C Shah Maria Argos Joyce Ho Karen Kim Martha Daviglus Philip Greenland Habibul Ahsan All of Us Research Program Investigators |
| author_facet | Briseis Aschebrook-Kilfoy Paul Zakin Andrew Craver Sameep Shah Muhammad G Kibriya Elizabeth Stepniak Andrea Ramirez Cheryl Clark Elizabeth Cohn Lucila Ohno-Machado Mine Cicek Eric Boerwinkle Sheri D Schully Stephen Mockrin Kelly Gebo Kelsey Mayo Francis Ratsimbazafy Alan Sanders Raj C Shah Maria Argos Joyce Ho Karen Kim Martha Daviglus Philip Greenland Habibul Ahsan All of Us Research Program Investigators |
| author_sort | Briseis Aschebrook-Kilfoy |
| collection | DOAJ |
| description | <h4>Introduction</h4>The NIH All of Us Research Program will have the scale and scope to enable research for a wide range of diseases, including cancer. The program's focus on diversity and inclusion promises a better understanding of the unequal burden of cancer. Preliminary cancer ascertainment in the All of Us cohort from two data sources (self-reported versus electronic health records (EHR)) is considered.<h4>Materials and methods</h4>This work was performed on data collected from the All of Us Research Program's 315,297 enrolled participants to date using the Researcher Workbench, where approved researchers can access and analyze All of Us data on cancer and other diseases. Cancer case ascertainment was performed using data from EHR and self-reported surveys across key factors. Distribution of cancer types and concordance of data sources by cancer site and demographics is analyzed.<h4>Results and discussion</h4>Data collected from 315,297 participants resulted in 13,298 cancer cases detected in the survey (in 89,261 participants), 23,520 cancer cases detected in the EHR (in 203,813 participants), and 7,123 cancer cases detected across both sources (in 62,497 participants). Key differences in survey completion by race/ethnicity impacted the makeup of cohorts when compared to cancer in the EHR and national NCI SEER data.<h4>Conclusions</h4>This study provides key insight into cancer detection in the All of Us Research Program and points to the existing strengths and limitations of All of Us as a platform for cancer research now and in the future. |
| first_indexed | 2024-04-09T18:22:25Z |
| format | Article |
| id | doaj.art-a9a0331030aa490ebb5140b246ff6e4c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T18:22:25Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a9a0331030aa490ebb5140b246ff6e4c2023-04-12T05:33:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027252210.1371/journal.pone.0272522An Overview of Cancer in the First 315,000 All of Us Participants.Briseis Aschebrook-KilfoyPaul ZakinAndrew CraverSameep ShahMuhammad G KibriyaElizabeth StepniakAndrea RamirezCheryl ClarkElizabeth CohnLucila Ohno-MachadoMine CicekEric BoerwinkleSheri D SchullyStephen MockrinKelly GeboKelsey MayoFrancis RatsimbazafyAlan SandersRaj C ShahMaria ArgosJoyce HoKaren KimMartha DaviglusPhilip GreenlandHabibul AhsanAll of Us Research Program Investigators<h4>Introduction</h4>The NIH All of Us Research Program will have the scale and scope to enable research for a wide range of diseases, including cancer. The program's focus on diversity and inclusion promises a better understanding of the unequal burden of cancer. Preliminary cancer ascertainment in the All of Us cohort from two data sources (self-reported versus electronic health records (EHR)) is considered.<h4>Materials and methods</h4>This work was performed on data collected from the All of Us Research Program's 315,297 enrolled participants to date using the Researcher Workbench, where approved researchers can access and analyze All of Us data on cancer and other diseases. Cancer case ascertainment was performed using data from EHR and self-reported surveys across key factors. Distribution of cancer types and concordance of data sources by cancer site and demographics is analyzed.<h4>Results and discussion</h4>Data collected from 315,297 participants resulted in 13,298 cancer cases detected in the survey (in 89,261 participants), 23,520 cancer cases detected in the EHR (in 203,813 participants), and 7,123 cancer cases detected across both sources (in 62,497 participants). Key differences in survey completion by race/ethnicity impacted the makeup of cohorts when compared to cancer in the EHR and national NCI SEER data.<h4>Conclusions</h4>This study provides key insight into cancer detection in the All of Us Research Program and points to the existing strengths and limitations of All of Us as a platform for cancer research now and in the future.https://doi.org/10.1371/journal.pone.0272522 |
| spellingShingle | Briseis Aschebrook-Kilfoy Paul Zakin Andrew Craver Sameep Shah Muhammad G Kibriya Elizabeth Stepniak Andrea Ramirez Cheryl Clark Elizabeth Cohn Lucila Ohno-Machado Mine Cicek Eric Boerwinkle Sheri D Schully Stephen Mockrin Kelly Gebo Kelsey Mayo Francis Ratsimbazafy Alan Sanders Raj C Shah Maria Argos Joyce Ho Karen Kim Martha Daviglus Philip Greenland Habibul Ahsan All of Us Research Program Investigators An Overview of Cancer in the First 315,000 All of Us Participants. PLoS ONE |
| title | An Overview of Cancer in the First 315,000 All of Us Participants. |
| title_full | An Overview of Cancer in the First 315,000 All of Us Participants. |
| title_fullStr | An Overview of Cancer in the First 315,000 All of Us Participants. |
| title_full_unstemmed | An Overview of Cancer in the First 315,000 All of Us Participants. |
| title_short | An Overview of Cancer in the First 315,000 All of Us Participants. |
| title_sort | overview of cancer in the first 315 000 all of us participants |
| url | https://doi.org/10.1371/journal.pone.0272522 |
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