Diversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization

Diversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization

Allosteric receptor-receptor interactions in GPCR heteromers appeared to introduce an intermolecular allosteric mechanism contributing to the diversity and bias in the protomers. Examples of dopamine D2R heteromerization are given to show how such allosteric mechanisms significantly change the recep...

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Bibliographic Details
Main Authors:	Kjell eFuxe, Alexander O Tarakanov, Wilber eRomero-Fernández, Luca eFerraro, Sergio eTanganelli, Małgorzata eFilip, Luigi Francesco Agnati, Pere eGarriga, Zaida eDiaz Cabiale, Dasiel Oscar Borroto-Escuela
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-05-01
Series:	Frontiers in Endocrinology
Subjects:	Oligomerization receptor-receptor interactions Dopamine receptor d G protein coupled receptor heterodimerization
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00071/full

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