Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study
Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying...
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MDPI AG
2020-12-01
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author | Masliza Hanuni Mat Ali Tuan Salwani Tuan Ismail Wan Norlina Wan Azman Najib Majdi Yaacob Norhayati Yahaya Nani Draman Wan Mohd Izani Wan Mohamed Mohd Shafie Abdullah Hanim Afzan Ibrahim Wan Nor Fazila Hafizan Wan Nik Mafauzy Mohamed |
author_facet | Masliza Hanuni Mat Ali Tuan Salwani Tuan Ismail Wan Norlina Wan Azman Najib Majdi Yaacob Norhayati Yahaya Nani Draman Wan Mohd Izani Wan Mohamed Mohd Shafie Abdullah Hanim Afzan Ibrahim Wan Nor Fazila Hafizan Wan Nik Mafauzy Mohamed |
author_sort | Masliza Hanuni Mat Ali |
collection | DOAJ |
description | Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (<i>n</i> = 64, hyperthyroid; <i>n</i> = 53 euthyroid; <i>n</i> = 18, hypothyroid) and healthy controls (<i>n</i> = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm<sup>2</sup>). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD. |
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issn | 2075-4418 |
language | English |
last_indexed | 2024-03-10T14:09:58Z |
publishDate | 2020-12-01 |
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spelling | doaj.art-a9a2a88aaaa242b4a096ee2645395cd52023-11-21T00:19:10ZengMDPI AGDiagnostics2075-44182020-12-011012107510.3390/diagnostics10121075Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional StudyMasliza Hanuni Mat Ali0Tuan Salwani Tuan Ismail1Wan Norlina Wan Azman2Najib Majdi Yaacob3Norhayati Yahaya4Nani Draman5Wan Mohd Izani Wan Mohamed6Mohd Shafie Abdullah7Hanim Afzan Ibrahim8Wan Nor Fazila Hafizan Wan Nik9Mafauzy Mohamed10Endocrine Unit, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaHospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaEndocrine Unit, Department of Medicine, Hospital Raja Perempuan Zainab 2, Kota Bharu 15200, Kelantan, MalaysiaHospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaEndocrine Unit, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaHospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaHospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaEndocrine Unit, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaThyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (<i>n</i> = 64, hyperthyroid; <i>n</i> = 53 euthyroid; <i>n</i> = 18, hypothyroid) and healthy controls (<i>n</i> = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm<sup>2</sup>). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.https://www.mdpi.com/2075-4418/10/12/1075hyperthyroidhypothyroideuthyroidvitamin dbone turn over markersbone mineral density |
spellingShingle | Masliza Hanuni Mat Ali Tuan Salwani Tuan Ismail Wan Norlina Wan Azman Najib Majdi Yaacob Norhayati Yahaya Nani Draman Wan Mohd Izani Wan Mohamed Mohd Shafie Abdullah Hanim Afzan Ibrahim Wan Nor Fazila Hafizan Wan Nik Mafauzy Mohamed Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study Diagnostics hyperthyroid hypothyroid euthyroid vitamin d bone turn over markers bone mineral density |
title | Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study |
title_full | Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study |
title_fullStr | Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study |
title_full_unstemmed | Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study |
title_short | Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study |
title_sort | comparison of vitamin d levels bone metabolic marker levels and bone mineral density among patients with thyroid disease a cross sectional study |
topic | hyperthyroid hypothyroid euthyroid vitamin d bone turn over markers bone mineral density |
url | https://www.mdpi.com/2075-4418/10/12/1075 |
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