Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye
The temporal distribution of drugs in the eye tissues after the topical dosing is required to study the efficacy of the drugs. Glaucoma is one of the primary causes of vision impairment around the world and timolol is used in the treatment of glaucoma in general. This paper contributes to developing...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | International Journal of Thermofluids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666202722001148 |
| _version_ | 1811207932736438272 |
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| author | Md Ashiqur Rahman Hasan Jamil Apon Mamun Rabbani Md Hasan Maruf ASM Shihavuddin |
| author_facet | Md Ashiqur Rahman Hasan Jamil Apon Mamun Rabbani Md Hasan Maruf ASM Shihavuddin |
| author_sort | Md Ashiqur Rahman |
| collection | DOAJ |
| description | The temporal distribution of drugs in the eye tissues after the topical dosing is required to study the efficacy of the drugs. Glaucoma is one of the primary causes of vision impairment around the world and timolol is used in the treatment of glaucoma in general. This paper contributes to developing a model to represent the more accurate biophysics of the human eye through the finite element method compared to other state-of-the-art simulation models. A 2D human-eye model is used to simulate the temporal distribution of timolol after topical dosing within the COMSOL Multiphysics environment. The biophysics of the human eye including temperature regulation, fluid flow in the anterior segment, convection, diffusion, reaction kinetics of timolol, and metabolic consumption are incorporated in the proposed simulation model. The temporal concentration of timolol is analyzed for seven ocular tissues (cornea, iris, sclera, aqueous humor, lens, ciliary body, and trabecular meshwork) in this work. The peak concentration of timolol takes place within 2500 s in the ocular tissues considered in the simulation and the peak in the anterior chamber is observed at 1150 s. The comparison based on the normalized concentration of timolol in the anterior chamber demonstrates that the results of the proposed ocular model comply close with the practical findings. The mean difference with the experimental results is lower in this study compared to the recent numerical works on timolol. The proposed model can be used for analyzing the physiological behavior of human eyes under different types of drug delivery with varying initial concentrations. |
| first_indexed | 2024-04-12T04:13:33Z |
| format | Article |
| id | doaj.art-a9a4aeff693242be99514d1aedbd51db |
| institution | Directory Open Access Journal |
| issn | 2666-2027 |
| language | English |
| last_indexed | 2024-04-12T04:13:33Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Thermofluids |
| spelling | doaj.art-a9a4aeff693242be99514d1aedbd51db2022-12-22T03:48:28ZengElsevierInternational Journal of Thermofluids2666-20272022-11-0116100251Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eyeMd Ashiqur Rahman0Hasan Jamil Apon1Mamun Rabbani2Md Hasan Maruf3ASM Shihavuddin4Department of Electrical and Electronic Engineering, Green University of Bangladesh, 220/D, Begum Rokeya Sarani, Dhaka 1207, Bangladesh; Corresponding author at: Green University of Bangladesh (GUB), 220/D, Begum Rokeya Sarani, Dhaka 1207, Bangladesh.Department of Electrical and Electronic Engineering, Islamic University of Technology, Gazipur, BangladeshDepartment of Biomedical Physics and Technology, University of Dhaka, Dhaka 1000, BangladeshDepartment of Electrical and Electronic Engineering, Green University of Bangladesh, 220/D, Begum Rokeya Sarani, Dhaka 1207, BangladeshDepartment of Electrical and Electronic Engineering, Green University of Bangladesh, 220/D, Begum Rokeya Sarani, Dhaka 1207, BangladeshThe temporal distribution of drugs in the eye tissues after the topical dosing is required to study the efficacy of the drugs. Glaucoma is one of the primary causes of vision impairment around the world and timolol is used in the treatment of glaucoma in general. This paper contributes to developing a model to represent the more accurate biophysics of the human eye through the finite element method compared to other state-of-the-art simulation models. A 2D human-eye model is used to simulate the temporal distribution of timolol after topical dosing within the COMSOL Multiphysics environment. The biophysics of the human eye including temperature regulation, fluid flow in the anterior segment, convection, diffusion, reaction kinetics of timolol, and metabolic consumption are incorporated in the proposed simulation model. The temporal concentration of timolol is analyzed for seven ocular tissues (cornea, iris, sclera, aqueous humor, lens, ciliary body, and trabecular meshwork) in this work. The peak concentration of timolol takes place within 2500 s in the ocular tissues considered in the simulation and the peak in the anterior chamber is observed at 1150 s. The comparison based on the normalized concentration of timolol in the anterior chamber demonstrates that the results of the proposed ocular model comply close with the practical findings. The mean difference with the experimental results is lower in this study compared to the recent numerical works on timolol. The proposed model can be used for analyzing the physiological behavior of human eyes under different types of drug delivery with varying initial concentrations.http://www.sciencedirect.com/science/article/pii/S2666202722001148Human-eyeConcentrationTimololDiffusionConvectionNumerical simulation |
| spellingShingle | Md Ashiqur Rahman Hasan Jamil Apon Mamun Rabbani Md Hasan Maruf ASM Shihavuddin Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye International Journal of Thermofluids Human-eye Concentration Timolol Diffusion Convection Numerical simulation |
| title | Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye |
| title_full | Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye |
| title_fullStr | Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye |
| title_full_unstemmed | Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye |
| title_short | Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye |
| title_sort | numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye |
| topic | Human-eye Concentration Timolol Diffusion Convection Numerical simulation |
| url | http://www.sciencedirect.com/science/article/pii/S2666202722001148 |
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