Clinical Impact Assessment and Utilization Prospects of the t(11:18) Chromosomal Translocation in Gastric MALT Lymphoma in Koreans: A Single Center Retrospective Analysis
Background/Aims: The gastric extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (gastric MALT lymphoma) are mostly related to Helicobacter pylori infections. However, chromosomal aberration involving translocation t(11;18) is also frequently reported in these patients. M...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Jin Publishing & Printing Co.
2023-01-01
|
| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5883&vmd=Full |
| _version_ | 1797271200428195840 |
|---|---|
| author | Hana Jung Da Wit Shin Dae Young Cheung Han Hee Lee Jin Il Kim Soo-Heon Park Tae Jung Kim |
| author_facet | Hana Jung Da Wit Shin Dae Young Cheung Han Hee Lee Jin Il Kim Soo-Heon Park Tae Jung Kim |
| author_sort | Hana Jung |
| collection | DOAJ |
| description | Background/Aims: The gastric extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (gastric MALT lymphoma) are mostly related to Helicobacter pylori infections. However, chromosomal aberration involving translocation t(11;18) is also frequently reported in these patients.
Methods: The study was a retrospective review and analysis of electronic medical records to assess the factors which affect complete remission (CR) in patients with gastric MALT lymphoma. Based on the medical records, subjects with gastric MALT lymphoma were enrolled consecutively from January 2004 to December 2021.
Results: Among the 77 subjects who were found with gastric MALT lymphoma in the database, 65 cases with complete records were analyzed. Of these, 66.2% (43/65) were H. pylori positive. Genetic analyses for t(11:18) were done on 41 subjects. The t(11:18) chromosomal translocation with MALT1:BIRC3 fusion was found in 31.7% (13/41) of the subjects. With H. pylori eradication therapy, 75% (21/28) of the subjects without t(11:18) achieved CR. However, only 23.1% (3/13) subjects with t(11:18) could achieve CR (p-value= 0.009). In the H. pylori-positive group, 85.7% (18/21) subjects without t(11:18) achieved CR with eradication therapy, but 71.4% (5/7) subjects with t(11:18) failed to achieve CR (p-value=0.004). In the H. pylori-negative group, 42.3% (3/7) of the subjects without t(11:18) achieved CR with eradication therapy. However, 83.3% (5/6) of H. pylori-negative subjects with t(11:18) failed to achieve CR with eradication therapy and needed additional radiotherapy (p-value=0.396).
Conclusions: H. pylori negativity and the presence of t(11:18) were both risk factors for failure to achieve CR with H. pylori eradication therapy as the first line of treatment. |
| first_indexed | 2024-03-07T13:58:21Z |
| format | Article |
| id | doaj.art-a9a5038b023e47139fa6473053ee82ee |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-03-07T13:58:21Z |
| publishDate | 2023-01-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-a9a5038b023e47139fa6473053ee82ee2024-03-07T07:22:46ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692023-01-01811293510.4166/kjg.2022.129Clinical Impact Assessment and Utilization Prospects of the t(11:18) Chromosomal Translocation in Gastric MALT Lymphoma in Koreans: A Single Center Retrospective AnalysisHana Jung0Da Wit Shin1Dae Young Cheung2https://orcid.org/0000-0003-4150-3555Han Hee Lee3Jin Il Kim4Soo-Heon Park5Tae Jung Kim6Departments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartments of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, KoreaBackground/Aims: The gastric extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (gastric MALT lymphoma) are mostly related to Helicobacter pylori infections. However, chromosomal aberration involving translocation t(11;18) is also frequently reported in these patients. Methods: The study was a retrospective review and analysis of electronic medical records to assess the factors which affect complete remission (CR) in patients with gastric MALT lymphoma. Based on the medical records, subjects with gastric MALT lymphoma were enrolled consecutively from January 2004 to December 2021. Results: Among the 77 subjects who were found with gastric MALT lymphoma in the database, 65 cases with complete records were analyzed. Of these, 66.2% (43/65) were H. pylori positive. Genetic analyses for t(11:18) were done on 41 subjects. The t(11:18) chromosomal translocation with MALT1:BIRC3 fusion was found in 31.7% (13/41) of the subjects. With H. pylori eradication therapy, 75% (21/28) of the subjects without t(11:18) achieved CR. However, only 23.1% (3/13) subjects with t(11:18) could achieve CR (p-value= 0.009). In the H. pylori-positive group, 85.7% (18/21) subjects without t(11:18) achieved CR with eradication therapy, but 71.4% (5/7) subjects with t(11:18) failed to achieve CR (p-value=0.004). In the H. pylori-negative group, 42.3% (3/7) of the subjects without t(11:18) achieved CR with eradication therapy. However, 83.3% (5/6) of H. pylori-negative subjects with t(11:18) failed to achieve CR with eradication therapy and needed additional radiotherapy (p-value=0.396). Conclusions: H. pylori negativity and the presence of t(11:18) were both risk factors for failure to achieve CR with H. pylori eradication therapy as the first line of treatment.https://www.kjg.or.kr/journal/view.html?uid=5883&vmd=Fullstomachextranodal marginal zone b cell lymphoma of malt typet(11:18) |
| spellingShingle | Hana Jung Da Wit Shin Dae Young Cheung Han Hee Lee Jin Il Kim Soo-Heon Park Tae Jung Kim Clinical Impact Assessment and Utilization Prospects of the t(11:18) Chromosomal Translocation in Gastric MALT Lymphoma in Koreans: A Single Center Retrospective Analysis The Korean Journal of Gastroenterology stomach extranodal marginal zone b cell lymphoma of malt type t(11:18) |
| title | Clinical Impact Assessment and Utilization Prospects of the t(11:18) Chromosomal Translocation in Gastric MALT Lymphoma in Koreans: A Single Center Retrospective Analysis |
| title_full | Clinical Impact Assessment and Utilization Prospects of the t(11:18) Chromosomal Translocation in Gastric MALT Lymphoma in Koreans: A Single Center Retrospective Analysis |
| title_fullStr | Clinical Impact Assessment and Utilization Prospects of the t(11:18) Chromosomal Translocation in Gastric MALT Lymphoma in Koreans: A Single Center Retrospective Analysis |
| title_full_unstemmed | Clinical Impact Assessment and Utilization Prospects of the t(11:18) Chromosomal Translocation in Gastric MALT Lymphoma in Koreans: A Single Center Retrospective Analysis |
| title_short | Clinical Impact Assessment and Utilization Prospects of the t(11:18) Chromosomal Translocation in Gastric MALT Lymphoma in Koreans: A Single Center Retrospective Analysis |
| title_sort | clinical impact assessment and utilization prospects of the t 11 18 chromosomal translocation in gastric malt lymphoma in koreans a single center retrospective analysis |
| topic | stomach extranodal marginal zone b cell lymphoma of malt type t(11:18) |
| url | https://www.kjg.or.kr/journal/view.html?uid=5883&vmd=Full |
| work_keys_str_mv | AT hanajung clinicalimpactassessmentandutilizationprospectsofthet1118chromosomaltranslocationingastricmaltlymphomainkoreansasinglecenterretrospectiveanalysis AT dawitshin clinicalimpactassessmentandutilizationprospectsofthet1118chromosomaltranslocationingastricmaltlymphomainkoreansasinglecenterretrospectiveanalysis AT daeyoungcheung clinicalimpactassessmentandutilizationprospectsofthet1118chromosomaltranslocationingastricmaltlymphomainkoreansasinglecenterretrospectiveanalysis AT hanheelee clinicalimpactassessmentandutilizationprospectsofthet1118chromosomaltranslocationingastricmaltlymphomainkoreansasinglecenterretrospectiveanalysis AT jinilkim clinicalimpactassessmentandutilizationprospectsofthet1118chromosomaltranslocationingastricmaltlymphomainkoreansasinglecenterretrospectiveanalysis AT sooheonpark clinicalimpactassessmentandutilizationprospectsofthet1118chromosomaltranslocationingastricmaltlymphomainkoreansasinglecenterretrospectiveanalysis AT taejungkim clinicalimpactassessmentandutilizationprospectsofthet1118chromosomaltranslocationingastricmaltlymphomainkoreansasinglecenterretrospectiveanalysis |