Esophageal adenocarcinoma with leukemoid reaction: a case report
Abstract Background Leukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm3, and a significant increase in early neutrophil precursors. LR may be a paraneoplastic manifestation of various malignant tumors. Tumor-related LR is a kind of neoplastic syndrome,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-04-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13019-019-0893-z |
| _version_ | 1819107884247547904 |
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| author | Ge Yu Huaijun Ji Chuizheng Meng Yixuan Huang Guogang Gao Chuanping Liu Shanlei Wang Lei Zhang Jin Ju |
| author_facet | Ge Yu Huaijun Ji Chuizheng Meng Yixuan Huang Guogang Gao Chuanping Liu Shanlei Wang Lei Zhang Jin Ju |
| author_sort | Ge Yu |
| collection | DOAJ |
| description | Abstract Background Leukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm3, and a significant increase in early neutrophil precursors. LR may be a paraneoplastic manifestation of various malignant tumors. Tumor-related LR is a kind of neoplastic syndrome, unrelated to an infection or other diseases. Case presentation A 74-year-old male visited a local doctor with a 20-day history of progressive dysphagia. The complete blood count revealed leucocytosis. Bone marrow aspirates and a biopsy confirmed LR and excluded chronic myelogenous leukemia. Following radical esophagectomy for an adenocarcinoma the WBC counts successively decreased to 10,450/mm3 and 8670/mm3 within 1 week and 1 month, respectively. Conclusion We report a rare case of esophageal adenocarcinoma complicated with excessive leucocytosis caused by paraneoplastic LR; we also present a review of literature and an investigation of the clinical features. To our knowledge, this is the first report of LR associated with esophageal adenocarcinoma. |
| first_indexed | 2024-12-22T03:01:07Z |
| format | Article |
| id | doaj.art-a9a52efdd17b4b839845ea2efe7e84ea |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-22T03:01:07Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-a9a52efdd17b4b839845ea2efe7e84ea2022-12-21T18:41:10ZengBMCJournal of Cardiothoracic Surgery1749-80902019-04-011411410.1186/s13019-019-0893-zEsophageal adenocarcinoma with leukemoid reaction: a case reportGe Yu0Huaijun Ji1Chuizheng Meng2Yixuan Huang3Guogang Gao4Chuanping Liu5Shanlei Wang6Lei Zhang7Jin Ju8Department of Thoracic Surgery, Weihai Municipal HospitalDepartment of Thoracic Surgery, Weihai Municipal HospitalDepartment of Thoracic Surgery, Weihai Municipal HospitalDepartment of Thoracic Surgery, Weihai Municipal HospitalDepartment of Thoracic Surgery, Weihai Municipal HospitalDepartment of Thoracic Surgery, Weihai Municipal HospitalDepartment of Thoracic Surgery, Weihai Municipal HospitalDepartment of Thoracic Surgery, Weihai Municipal HospitalDepartment of Thoracic Surgery, Weihai Municipal HospitalAbstract Background Leukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm3, and a significant increase in early neutrophil precursors. LR may be a paraneoplastic manifestation of various malignant tumors. Tumor-related LR is a kind of neoplastic syndrome, unrelated to an infection or other diseases. Case presentation A 74-year-old male visited a local doctor with a 20-day history of progressive dysphagia. The complete blood count revealed leucocytosis. Bone marrow aspirates and a biopsy confirmed LR and excluded chronic myelogenous leukemia. Following radical esophagectomy for an adenocarcinoma the WBC counts successively decreased to 10,450/mm3 and 8670/mm3 within 1 week and 1 month, respectively. Conclusion We report a rare case of esophageal adenocarcinoma complicated with excessive leucocytosis caused by paraneoplastic LR; we also present a review of literature and an investigation of the clinical features. To our knowledge, this is the first report of LR associated with esophageal adenocarcinoma.http://link.springer.com/article/10.1186/s13019-019-0893-zLeukemoid reaction (LR)HyperleukocytosisEsophageal adenocarcinomaEsophagectomy |
| spellingShingle | Ge Yu Huaijun Ji Chuizheng Meng Yixuan Huang Guogang Gao Chuanping Liu Shanlei Wang Lei Zhang Jin Ju Esophageal adenocarcinoma with leukemoid reaction: a case report Journal of Cardiothoracic Surgery Leukemoid reaction (LR) Hyperleukocytosis Esophageal adenocarcinoma Esophagectomy |
| title | Esophageal adenocarcinoma with leukemoid reaction: a case report |
| title_full | Esophageal adenocarcinoma with leukemoid reaction: a case report |
| title_fullStr | Esophageal adenocarcinoma with leukemoid reaction: a case report |
| title_full_unstemmed | Esophageal adenocarcinoma with leukemoid reaction: a case report |
| title_short | Esophageal adenocarcinoma with leukemoid reaction: a case report |
| title_sort | esophageal adenocarcinoma with leukemoid reaction a case report |
| topic | Leukemoid reaction (LR) Hyperleukocytosis Esophageal adenocarcinoma Esophagectomy |
| url | http://link.springer.com/article/10.1186/s13019-019-0893-z |
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