Adaptation to Overflow Metabolism by Mutations That Impair tRNA Modification in Experimentally Evolved Bacteria

Adaptation to Overflow Metabolism by Mutations That Impair tRNA Modification in Experimentally Evolved Bacteria

ABSTRACT When microbes grow in foreign nutritional environments, selection may enrich mutations in unexpected pathways connecting growth and homeostasis. An evolution experiment designed to identify beneficial mutations in Burkholderia cenocepacia captured six independent nonsynonymous substitutions...

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Bibliographic Details
Main Authors: Marc J. Muraski, Emil M. Nilsson, Melissa J. Fritz, Anthony R. Richardson, Rebecca W. Alexander, Vaughn S. Cooper
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
experimental evolution
tRNA modification
tradeoff
translational control
Online Access:https://journals.asm.org/doi/10.1128/mbio.00287-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00287-23

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