What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?
One of the key features associated with the substantial increase in life expectancy for individuals with CF is an elevated predisposition to cancer, firmly established by recent studies involving large cohorts. With the recent advances in cystic fibrosis transmembrane conductance regulator (CFTR) mo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/9/3133 |
| _version_ | 1797569360807591936 |
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| author | Margarida D. Amaral Margarida C. Quaresma Ines Pankonien |
| author_facet | Margarida D. Amaral Margarida C. Quaresma Ines Pankonien |
| author_sort | Margarida D. Amaral |
| collection | DOAJ |
| description | One of the key features associated with the substantial increase in life expectancy for individuals with CF is an elevated predisposition to cancer, firmly established by recent studies involving large cohorts. With the recent advances in cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies and the increased long-term survival rate of individuals with cystic fibrosis (CF), this is a novel challenge emerging at the forefront of this disease. However, the mechanisms linking dysfunctional CFTR to carcinogenesis have yet to be unravelled. Clues to this challenging open question emerge from key findings in an increasing number of studies showing that CFTR plays a role in fundamental cellular processes such as foetal development, epithelial differentiation/polarization, and regeneration, as well as in epithelial–mesenchymal transition (EMT). Here, we provide state-of-the-art descriptions on the moonlight roles of CFTR in these processes, highlighting how they can contribute to novel therapeutic strategies. However, such roles are still largely unknown, so we need rapid progress in the elucidation of the underlying mechanisms to find the answers and thus tailor the most appropriate therapeutic approaches. |
| first_indexed | 2024-03-10T20:09:44Z |
| format | Article |
| id | doaj.art-a9a7c7353da44332afa414ce348fcb19 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:09:44Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a9a7c7353da44332afa414ce348fcb192023-11-19T23:00:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01219313310.3390/ijms21093133What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?Margarida D. Amaral0Margarida C. Quaresma1Ines Pankonien2BioISI—Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, PortugalBioISI—Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, PortugalBioISI—Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, PortugalOne of the key features associated with the substantial increase in life expectancy for individuals with CF is an elevated predisposition to cancer, firmly established by recent studies involving large cohorts. With the recent advances in cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies and the increased long-term survival rate of individuals with cystic fibrosis (CF), this is a novel challenge emerging at the forefront of this disease. However, the mechanisms linking dysfunctional CFTR to carcinogenesis have yet to be unravelled. Clues to this challenging open question emerge from key findings in an increasing number of studies showing that CFTR plays a role in fundamental cellular processes such as foetal development, epithelial differentiation/polarization, and regeneration, as well as in epithelial–mesenchymal transition (EMT). Here, we provide state-of-the-art descriptions on the moonlight roles of CFTR in these processes, highlighting how they can contribute to novel therapeutic strategies. However, such roles are still largely unknown, so we need rapid progress in the elucidation of the underlying mechanisms to find the answers and thus tailor the most appropriate therapeutic approaches.https://www.mdpi.com/1422-0067/21/9/3133carcinogenesiscystic fibrosisepithelial–mesenchymal transition EMTepithelial differentiationepithelial regenerationwound healing |
| spellingShingle | Margarida D. Amaral Margarida C. Quaresma Ines Pankonien What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer? International Journal of Molecular Sciences carcinogenesis cystic fibrosis epithelial–mesenchymal transition EMT epithelial differentiation epithelial regeneration wound healing |
| title | What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer? |
| title_full | What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer? |
| title_fullStr | What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer? |
| title_full_unstemmed | What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer? |
| title_short | What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer? |
| title_sort | what role does cftr play in development differentiation regeneration and cancer |
| topic | carcinogenesis cystic fibrosis epithelial–mesenchymal transition EMT epithelial differentiation epithelial regeneration wound healing |
| url | https://www.mdpi.com/1422-0067/21/9/3133 |
| work_keys_str_mv | AT margaridadamaral whatroledoescftrplayindevelopmentdifferentiationregenerationandcancer AT margaridacquaresma whatroledoescftrplayindevelopmentdifferentiationregenerationandcancer AT inespankonien whatroledoescftrplayindevelopmentdifferentiationregenerationandcancer |