Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout
ObjectivePeripheral neuropathies (PNs) are a group of disorders that affect the peripheral nervous system. PN in gout has been scarcely described. This study is conducted to determine the prevalence and related risk factors of PN, as assessed by vibration perception threshold (VPT) in patients with...
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.789631/full |
| _version_ | 1818872417754284032 |
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| author | Kaifeng Guo Kaifeng Guo Nan Liang Nan Liang Mian Wu Lihui Chen Haibing Chen |
| author_facet | Kaifeng Guo Kaifeng Guo Nan Liang Nan Liang Mian Wu Lihui Chen Haibing Chen |
| author_sort | Kaifeng Guo |
| collection | DOAJ |
| description | ObjectivePeripheral neuropathies (PNs) are a group of disorders that affect the peripheral nervous system. PN in gout has been scarcely described. This study is conducted to determine the prevalence and related risk factors of PN, as assessed by vibration perception threshold (VPT) in patients with gout.MethodsA total of 442 patients were included in the cross-sectional study. The VPT values were measured by using the Biothesiometer sensory quantitative tester on each patient. The VPT value of either limb higher than 15 V was considered abnormal and is considered to have PN. The univariate and multivariate logistic regression models were used to identify risk factors for PN in patients with gout.ResultsWe included 442 patients with gout, 97.5% men, 26.9% tophaceous gout, mean age 45.5 ± 15.2 years, and 7.4 ± 4.6 years of disease duration. The prevalence of PN in patients with gout was 11.1%. Patients in the abnormal VPT group were older, had a longer gout duration, and had significantly higher levels of waist circumference, waist-to-hip ratio, systolic blood pressure (SBP), and erythrocyte sedimentation rate (ESR), as compared to patients in the normal vibration group (P < 0.05). The univariate logistic regression analysis demonstrated that there was a significant association between abnormal VPT and age, duration of gout, SBP, C-reactive protein, ESR, presence of tophi, and estimated glomerular filtration rate (eGFR) in all the subjects (P < 0.05). The multivariate logistic regression analysis indicated that age (odds ratio, 1.094) and presence of tophi (odds ratio, 1.048) were independent risk factors for PN in patients with gout.ConclusionThe abnormal VPT was significantly correlated with age and presence of tophi in patients with gout and the VPT level may be useful as a screening tool for assessment of PN in gout. |
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| language | English |
| last_indexed | 2024-12-19T12:38:29Z |
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| series | Frontiers in Neurology |
| spelling | doaj.art-a9a811634f9c46e0b18138387050efc92022-12-21T20:21:03ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-02-011310.3389/fneur.2022.789631789631Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With GoutKaifeng Guo0Kaifeng Guo1Nan Liang2Nan Liang3Mian Wu4Lihui Chen5Haibing Chen6Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, ChinaDepartment of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaObjectivePeripheral neuropathies (PNs) are a group of disorders that affect the peripheral nervous system. PN in gout has been scarcely described. This study is conducted to determine the prevalence and related risk factors of PN, as assessed by vibration perception threshold (VPT) in patients with gout.MethodsA total of 442 patients were included in the cross-sectional study. The VPT values were measured by using the Biothesiometer sensory quantitative tester on each patient. The VPT value of either limb higher than 15 V was considered abnormal and is considered to have PN. The univariate and multivariate logistic regression models were used to identify risk factors for PN in patients with gout.ResultsWe included 442 patients with gout, 97.5% men, 26.9% tophaceous gout, mean age 45.5 ± 15.2 years, and 7.4 ± 4.6 years of disease duration. The prevalence of PN in patients with gout was 11.1%. Patients in the abnormal VPT group were older, had a longer gout duration, and had significantly higher levels of waist circumference, waist-to-hip ratio, systolic blood pressure (SBP), and erythrocyte sedimentation rate (ESR), as compared to patients in the normal vibration group (P < 0.05). The univariate logistic regression analysis demonstrated that there was a significant association between abnormal VPT and age, duration of gout, SBP, C-reactive protein, ESR, presence of tophi, and estimated glomerular filtration rate (eGFR) in all the subjects (P < 0.05). The multivariate logistic regression analysis indicated that age (odds ratio, 1.094) and presence of tophi (odds ratio, 1.048) were independent risk factors for PN in patients with gout.ConclusionThe abnormal VPT was significantly correlated with age and presence of tophi in patients with gout and the VPT level may be useful as a screening tool for assessment of PN in gout.https://www.frontiersin.org/articles/10.3389/fneur.2022.789631/fullgoutperipheral neuropathyvibration perception thresholdtophiprevalence |
| spellingShingle | Kaifeng Guo Kaifeng Guo Nan Liang Nan Liang Mian Wu Lihui Chen Haibing Chen Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout Frontiers in Neurology gout peripheral neuropathy vibration perception threshold tophi prevalence |
| title | Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout |
| title_full | Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout |
| title_fullStr | Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout |
| title_full_unstemmed | Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout |
| title_short | Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout |
| title_sort | prevalence and risk factors for peripheral neuropathy in chinese patients with gout |
| topic | gout peripheral neuropathy vibration perception threshold tophi prevalence |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.789631/full |
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