METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation

METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation

Abstract Background Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high risk for rapid and fatal progression. Despite existing therapy approaches, the 5-year event-free survival (EFS) for patients with advanced NBL...

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Bibliographic Details
Main Authors: Ying Huang, Jieyi Ma, Cuiyun Yang, Paijia Wei, Minghui Yang, Hui Han, Hua Dong Chen, Tianfang Yue, Shu Xiao, Xuanyu Chen, Zuoqing Li, Yanlai Tang, Jiesi Luo, Shuibin Lin, Libin Huang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Biomarker Research
Subjects:
Neuroblastoma
N7-methylguanosine
Epigenetics
Online Access:https://doi.org/10.1186/s40364-022-00414-z

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