Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae)
Alho do mato (Cipura paludosa, Iridaceae) is a medicinal plant found in the Amazon rain forest, North of Brazil. It has been used to treat algic, inflammatory and infectious processes. The aim of this study was to evaluate the anti-inflammatory and antinociceptive action of the crude Cipura paludosa...
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| Format: | Article |
| Language: | English |
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Instituto Nacional de Pesquisas da Amazônia
2014-06-01
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| Series: | Acta Amazonica |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000200012&tlng=en |
| _version_ | 1818972550953172992 |
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| author | José Antônio Paixão da Silva Neto Larissa Dias Menezes Gúbio Oliveira Gomes Elise Marques Freire Cunha Mariângela Soares de Azevedo Vania Moraes Ferreira Mônica Valero da Silva |
| author_facet | José Antônio Paixão da Silva Neto Larissa Dias Menezes Gúbio Oliveira Gomes Elise Marques Freire Cunha Mariângela Soares de Azevedo Vania Moraes Ferreira Mônica Valero da Silva |
| author_sort | José Antônio Paixão da Silva Neto |
| collection | DOAJ |
| description | Alho do mato (Cipura paludosa, Iridaceae) is a medicinal plant found in the Amazon rain forest, North of Brazil. It has been used to treat algic, inflammatory and infectious processes. The aim of this study was to evaluate the anti-inflammatory and antinociceptive action of the crude Cipura paludosa ethanolic extract at concentrations ranging between 2.0 and 4.0% in Oil and Water cream formulations for topical use. The physical-chemical stability of the formulations was monitored over a six-month period with the use of accelerated stability tests. In order to evaluate the anti-inflammatory and antinociceptive activities, we used a paw edema test induced by carrageenan and a formalin test, respectively. The paw edema test showed that there was a statistical difference in the control group in relation to the treatments. The formalin test did not confirm antinociceptive action of the treatments with the extract in the early phase of the test. However, statistical difference was confirmed for the treatments in relation to the control in the late phase. The antinociceptive and anti-inflammatory activities of Cipura paludosa preparations, as demonstrated in the results, at least partially support the ethno-medical uses of this plant. |
| first_indexed | 2024-12-20T15:10:04Z |
| format | Article |
| id | doaj.art-a9a8afa9ca7e467f855c70eb66b194d4 |
| institution | Directory Open Access Journal |
| issn | 0044-5967 |
| language | English |
| last_indexed | 2024-12-20T15:10:04Z |
| publishDate | 2014-06-01 |
| publisher | Instituto Nacional de Pesquisas da Amazônia |
| record_format | Article |
| series | Acta Amazonica |
| spelling | doaj.art-a9a8afa9ca7e467f855c70eb66b194d42022-12-21T19:36:21ZengInstituto Nacional de Pesquisas da AmazôniaActa Amazonica0044-59672014-06-0144226327010.1590/S0044-59672014000200012Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae)José Antônio Paixão da Silva Neto0Larissa Dias Menezes1Gúbio Oliveira Gomes2Elise Marques Freire Cunha3Mariângela Soares de Azevedo4Vania Moraes Ferreira5Mônica Valero da Silva6Universidade de BrasíliaUniversidade de BrasíliaUniversidade de BrasíliaUniversidade Federal de RondôniaUniversidade Federal de RondôniaUniversidade de BrasíliaUniversidade de BrasíliaAlho do mato (Cipura paludosa, Iridaceae) is a medicinal plant found in the Amazon rain forest, North of Brazil. It has been used to treat algic, inflammatory and infectious processes. The aim of this study was to evaluate the anti-inflammatory and antinociceptive action of the crude Cipura paludosa ethanolic extract at concentrations ranging between 2.0 and 4.0% in Oil and Water cream formulations for topical use. The physical-chemical stability of the formulations was monitored over a six-month period with the use of accelerated stability tests. In order to evaluate the anti-inflammatory and antinociceptive activities, we used a paw edema test induced by carrageenan and a formalin test, respectively. The paw edema test showed that there was a statistical difference in the control group in relation to the treatments. The formalin test did not confirm antinociceptive action of the treatments with the extract in the early phase of the test. However, statistical difference was confirmed for the treatments in relation to the control in the late phase. The antinociceptive and anti-inflammatory activities of Cipura paludosa preparations, as demonstrated in the results, at least partially support the ethno-medical uses of this plant.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000200012&tlng=enOil and Water Creammedicinal plantpaw edema testformalin test |
| spellingShingle | José Antônio Paixão da Silva Neto Larissa Dias Menezes Gúbio Oliveira Gomes Elise Marques Freire Cunha Mariângela Soares de Azevedo Vania Moraes Ferreira Mônica Valero da Silva Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae) Acta Amazonica Oil and Water Cream medicinal plant paw edema test formalin test |
| title | Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae) |
| title_full | Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae) |
| title_fullStr | Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae) |
| title_full_unstemmed | Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae) |
| title_short | Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae) |
| title_sort | evaluation of antinociceptive and anti inflammatory activities of the topical preparation of cipura paludosa iridaceae |
| topic | Oil and Water Cream medicinal plant paw edema test formalin test |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000200012&tlng=en |
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