An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment
This paper proposes a compact bioelectronics sensing platform, including a multi-channel electrode, intracranial electroencephalogram (iEEG) recorder, adjustable galvanometer, and shunt-current conduction circuit pathway. The developed implantable electrode made of polyurethane-insulated stainless-s...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/4/247 |
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| author | Changhua You Lei Yao Pan Yao Li Li Ping Ding Shuli Liang Chunxiu Liu Ning Xue |
| author_facet | Changhua You Lei Yao Pan Yao Li Li Ping Ding Shuli Liang Chunxiu Liu Ning Xue |
| author_sort | Changhua You |
| collection | DOAJ |
| description | This paper proposes a compact bioelectronics sensing platform, including a multi-channel electrode, intracranial electroencephalogram (iEEG) recorder, adjustable galvanometer, and shunt-current conduction circuit pathway. The developed implantable electrode made of polyurethane-insulated stainless-steel materials is capable of recording iEEG signals and shunt-current conduction. The electrochemical impedance of the conduction, ground/reference, and working electrode were characterized in phosphate buffer saline solution, revealing in vitro results of 517.2 Ω@1 kHz (length of 0.1 mm, diameter of 0.8 mm), 1.374 kΩ@1 kHz (length of 0.3 mm, diameter of 0.1 mm), and 3.188 kΩ@1 kHz (length of 0.1 mm, diameter of 0.1 mm), respectively. On-bench measurement of the system revealed that the input noise of the system is less than 2 μVrms, the signal frequency bandwidth range is 1 Hz~10 kHz, and the shunt-current detection range is 0.1~3000 μA with an accuracy of above 99.985%. The electrode was implanted in the CA1 region of the right hippocampus of rats for the in vivo experiments. Kainic acid (KA)-induced seizures were detected through iEEG monitoring, and the induced shunt-current was successfully measured and conducted out of the brain through the designed circuit-body path, which verifies the potential of current conduction for the treatment of epilepsy. |
| first_indexed | 2024-03-09T11:05:22Z |
| format | Article |
| id | doaj.art-a9aa3402e9514913adb40ec0068c3068 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T11:05:22Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-a9aa3402e9514913adb40ec0068c30682023-12-01T00:58:32ZengMDPI AGBiosensors2079-63742022-04-0112424710.3390/bios12040247An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy TreatmentChanghua You0Lei Yao1Pan Yao2Li Li3Ping Ding4Shuli Liang5Chunxiu Liu6Ning Xue7State Key Laboratory of Transducer Technology, Aerospace Information Research Institute (AIR), Chinese Academy of Sciences, Beijing 100190, ChinaSchool of Microelectronics, Shanghai University, Shanghai 200444, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute (AIR), Chinese Academy of Sciences, Beijing 100190, ChinaSPF Biotechnology Co., Ltd., Beijing 102100, ChinaFunctional Neurosurgery Department, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, ChinaFunctional Neurosurgery Department, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute (AIR), Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute (AIR), Chinese Academy of Sciences, Beijing 100190, ChinaThis paper proposes a compact bioelectronics sensing platform, including a multi-channel electrode, intracranial electroencephalogram (iEEG) recorder, adjustable galvanometer, and shunt-current conduction circuit pathway. The developed implantable electrode made of polyurethane-insulated stainless-steel materials is capable of recording iEEG signals and shunt-current conduction. The electrochemical impedance of the conduction, ground/reference, and working electrode were characterized in phosphate buffer saline solution, revealing in vitro results of 517.2 Ω@1 kHz (length of 0.1 mm, diameter of 0.8 mm), 1.374 kΩ@1 kHz (length of 0.3 mm, diameter of 0.1 mm), and 3.188 kΩ@1 kHz (length of 0.1 mm, diameter of 0.1 mm), respectively. On-bench measurement of the system revealed that the input noise of the system is less than 2 μVrms, the signal frequency bandwidth range is 1 Hz~10 kHz, and the shunt-current detection range is 0.1~3000 μA with an accuracy of above 99.985%. The electrode was implanted in the CA1 region of the right hippocampus of rats for the in vivo experiments. Kainic acid (KA)-induced seizures were detected through iEEG monitoring, and the induced shunt-current was successfully measured and conducted out of the brain through the designed circuit-body path, which verifies the potential of current conduction for the treatment of epilepsy.https://www.mdpi.com/2079-6374/12/4/247neural electrophysiological signal recordingcurrent conduction treatmentconduction electrodetemporal lobe epilepsy |
| spellingShingle | Changhua You Lei Yao Pan Yao Li Li Ping Ding Shuli Liang Chunxiu Liu Ning Xue An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment Biosensors neural electrophysiological signal recording current conduction treatment conduction electrode temporal lobe epilepsy |
| title | An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment |
| title_full | An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment |
| title_fullStr | An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment |
| title_full_unstemmed | An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment |
| title_short | An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment |
| title_sort | ieeg recording and adjustable shunt current conduction platform for epilepsy treatment |
| topic | neural electrophysiological signal recording current conduction treatment conduction electrode temporal lobe epilepsy |
| url | https://www.mdpi.com/2079-6374/12/4/247 |
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