Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus
Abstract Background Toxoplasmosis is probably one of the most common parasitic infections of humans. While infection of healthy adults is usually relatively mild, serious disease can result in utero or when the host is immuno-compromised. Toxoplasmosis in diabetic patients may occur due to recently...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-02-01
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| Series: | Bulletin of the National Research Centre |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s42269-019-0059-0 |
| _version_ | 1818020999127367680 |
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| author | Hala M. Khattab Safeya O. El Bassiouni Manal H. Abuelela Dalia O. Abd Elsalam |
| author_facet | Hala M. Khattab Safeya O. El Bassiouni Manal H. Abuelela Dalia O. Abd Elsalam |
| author_sort | Hala M. Khattab |
| collection | DOAJ |
| description | Abstract Background Toxoplasmosis is probably one of the most common parasitic infections of humans. While infection of healthy adults is usually relatively mild, serious disease can result in utero or when the host is immuno-compromised. Toxoplasmosis in diabetic patients may occur due to recently acquired acute infection or they may suffer from dissemination of reactivated latent infection. In the present study, the antinuclear antibody prevalence was tested to determine the possible relationship with Toxoplasma seroprevalence and clinical findings in type I diabetic patients. Methods Toxoplasma gondii antibodies were tested serologically in 60 patients of type I diabetes mellitus and 60 controls using ELISA technique. Results The seropositivity for anti-Toxoplasma IgG antibodies in the study groups was 45% in type I diabetes mellitus patients (group 1) and 23.3% in the control (group 2) with p value = 0.012 showing a statistically significant difference between groups, while only three patients of diabetes type1 group were positive for anti-Toxoplasma IgM with p value = 0.244 showing no statistically significant differences between the two groups. Results showed that only one patient of diabetes type 1 (group1) had positive ANA and one control (group2) had positive ANA. Thus, no correlation could be detected from such results. Conclusion The study results showed a statistically significantly higher proportion (45%) of seropositivity anti-Toxoplasma IgG antibodies among type I diabetes mellitus patients compared to 23.3% among the control group, while there was no association could be detected between the studied groups regarding the ANA. |
| first_indexed | 2024-04-14T08:13:07Z |
| format | Article |
| id | doaj.art-a9abf608260f445494a8321c626d81b3 |
| institution | Directory Open Access Journal |
| issn | 2522-8307 |
| language | English |
| last_indexed | 2024-04-14T08:13:07Z |
| publishDate | 2019-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj.art-a9abf608260f445494a8321c626d81b32022-12-22T02:04:29ZengSpringerOpenBulletin of the National Research Centre2522-83072019-02-014311710.1186/s42269-019-0059-0Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitusHala M. Khattab0Safeya O. El Bassiouni1Manal H. Abuelela2Dalia O. Abd Elsalam3Medical Parasitology Department, Research Institute of OphthalmologyMedical Parasitology Department, Faculty of Medicine, Cairo UniversityPublic Health Department, Research Institute of OphthalmologyMedical Parasitology Department, Research Institute of OphthalmologyAbstract Background Toxoplasmosis is probably one of the most common parasitic infections of humans. While infection of healthy adults is usually relatively mild, serious disease can result in utero or when the host is immuno-compromised. Toxoplasmosis in diabetic patients may occur due to recently acquired acute infection or they may suffer from dissemination of reactivated latent infection. In the present study, the antinuclear antibody prevalence was tested to determine the possible relationship with Toxoplasma seroprevalence and clinical findings in type I diabetic patients. Methods Toxoplasma gondii antibodies were tested serologically in 60 patients of type I diabetes mellitus and 60 controls using ELISA technique. Results The seropositivity for anti-Toxoplasma IgG antibodies in the study groups was 45% in type I diabetes mellitus patients (group 1) and 23.3% in the control (group 2) with p value = 0.012 showing a statistically significant difference between groups, while only three patients of diabetes type1 group were positive for anti-Toxoplasma IgM with p value = 0.244 showing no statistically significant differences between the two groups. Results showed that only one patient of diabetes type 1 (group1) had positive ANA and one control (group2) had positive ANA. Thus, no correlation could be detected from such results. Conclusion The study results showed a statistically significantly higher proportion (45%) of seropositivity anti-Toxoplasma IgG antibodies among type I diabetes mellitus patients compared to 23.3% among the control group, while there was no association could be detected between the studied groups regarding the ANA.http://link.springer.com/article/10.1186/s42269-019-0059-0Toxoplasma gondiiDiabetes mellitusANAELISAIgG and IgM antibodies |
| spellingShingle | Hala M. Khattab Safeya O. El Bassiouni Manal H. Abuelela Dalia O. Abd Elsalam Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus Bulletin of the National Research Centre Toxoplasma gondii Diabetes mellitus ANA ELISA IgG and IgM antibodies |
| title | Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus |
| title_full | Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus |
| title_fullStr | Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus |
| title_full_unstemmed | Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus |
| title_short | Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus |
| title_sort | seroprevalence of toxoplasma gondii among a group of egyptian patients with type i diabetes mellitus |
| topic | Toxoplasma gondii Diabetes mellitus ANA ELISA IgG and IgM antibodies |
| url | http://link.springer.com/article/10.1186/s42269-019-0059-0 |
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