Andrographolide Promotes Interaction Between Endothelin-Dependent EDNRA/EDNRB and Myocardin-SRF to Regulate Pathological Vascular Remodeling

Andrographolide Promotes Interaction Between Endothelin-Dependent EDNRA/EDNRB and Myocardin-SRF to Regulate Pathological Vascular Remodeling

IntroductionPathological vascular remodeling is a hallmark of various vascular diseases. Smooth muscle cell (SMC) phenotypic switching plays a pivotal role during pathological vascular remodeling. The mechanism of how to regulate SMC phenotypic switching still needs to be defined. This study aims to...

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Bibliographic Details
Main Authors: Wangming Hu, Xiao Wu, Zhong Jin, Zheng Wang, Qiru Guo, Zixian Chen, Song Zhu, Haidi Zhang, Jian Huo, Lingling Zhang, Xin Zhou, Lan Yang, Huan Xu, Liangqing Shi, Yong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Andrographolide
EDNRA
EDNRB
Myocardin-SRF
CArG box
pathological vascular remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.783872/full

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